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Assay Detail

CHEMBL4040321

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]mibolerone from human androgen receptor expressed in African green monkey COS cells after 3.5 hrs by scintillation and luminescene counting
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Androgen receptor (CHEMBL1871)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Structure-Based Approach To Identify 5-[4-Hydroxyphenyl]pyrrole-2-carbonitrile Derivatives as Potent and Tissue Selective Androgen Receptor Modulators.
Unwalla R, Mousseau JJ, Fadeyi OO, Choi C, Parris K, Hu B, Kenney T, Chippari S, McNally C, Vishwanathan K, Kilbourne E, Thompson C, Nagpal S, Wrobel J, Yudt M, Morris CA, Powell D, Gilbert AM, Chekler ELP.
J Med Chem (2017) 60 : 6451 -6457
PubMed 28696695 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 7.58 8.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4088158 1 8.85
CHEMBL4095364 1 8.80
CHEMBL4065842 1 8.54
CHEMBL4095883 1 8.49
CHEMBL4079377 1 8.43
CHEMBL4072730 1 8.31
CHEMBL4087256 1 8.20
CHEMBL4066319 1 8.17
CHEMBL4103641 1 8.15
CHEMBL4061510 1 8.09
CHEMBL4088572 1 7.96
CHEMBL4073399 1 7.83
CHEMBL4074555 1 7.54
CHEMBL4069026 1 7.43
CHEMBL4062016 1 7.32
CHEMBL4068562 1 7.23
CHEMBL4100251 1 7.19
CHEMBL4104046 1 7.17
CHEMBL4091403 1 7.07
CHEMBL4060340 1 6.90
CHEMBL4073869 1 6.78
CHEMBL4087674 1 6.48
CHEMBL4074927 1 5.83
CHEMBL4080698 1 5.22
CHEMBL4098744 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4088158 IC50 = 1.4 nM 8.85
CHEMBL4095364 IC50 = 1.6 nM 8.80
CHEMBL4065842 IC50 = 2.9 nM 8.54
CHEMBL4095883 IC50 = 3.2 nM 8.49
CHEMBL4079377 IC50 = 3.7 nM 8.43
CHEMBL4072730 IC50 = 4.9 nM 8.31
CHEMBL4087256 IC50 = 6.3 nM 8.20
CHEMBL4066319 IC50 = 6.8 nM 8.17
CHEMBL4103641 IC50 = 7.1 nM 8.15
CHEMBL4061510 IC50 = 8.1 nM 8.09
CHEMBL4088572 IC50 = 11.1 nM 7.96
CHEMBL4073399 IC50 = 14.8 nM 7.83
CHEMBL4074555 IC50 = 28.7 nM 7.54
CHEMBL4069026 IC50 = 36.8 nM 7.43
CHEMBL4062016 IC50 = 47.6 nM 7.32
CHEMBL4068562 IC50 = 59.0 nM 7.23
CHEMBL4100251 IC50 = 65.0 nM 7.19
CHEMBL4104046 IC50 = 67.4 nM 7.17
CHEMBL4091403 IC50 = 85.8 nM 7.07
CHEMBL4060340 IC50 = 127.1 nM 6.90
CHEMBL4073869 IC50 = 166.9 nM 6.78
CHEMBL4087674 IC50 = 330.2 nM 6.48
CHEMBL4074927 IC50 = 1465.9 nM 5.83
CHEMBL4080698 IC50 = 6032.0 nM 5.22
CHEMBL4098744 IC50 > 10000.0 nM -