Assay Detail
Binding
CHEMBL4040507
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assay
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Kinetic Profiling of 7-Aryl-1,2,4-triazolo[4,3-a]pyridines: Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 45 | 8.00 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4074664 | — | — | 1 | 9.00 |
| CHEMBL4087196 | — | — | 1 | 8.96 |
| CHEMBL4073628 | — | — | 1 | 8.92 |
| CHEMBL4063313 | — | — | 1 | 8.82 |
| CHEMBL4093657 | — | — | 1 | 8.70 |
| CHEMBL4067298 | — | — | 1 | 8.68 |
| CHEMBL4088239 | — | — | 1 | 8.66 |
| CHEMBL4080973 | — | — | 1 | 8.60 |
| CHEMBL4091370 | — | — | 1 | 8.54 |
| CHEMBL4077609 | — | — | 1 | 8.52 |
| CHEMBL4104081 | — | — | 1 | 8.52 |
| CHEMBL4093792 | — | — | 1 | 8.48 |
| CHEMBL4067421 | — | — | 1 | 8.47 |
| CHEMBL4064589 | — | — | 1 | 8.42 |
| CHEMBL4060306 | — | — | 1 | 8.21 |
| CHEMBL4101354 | — | — | 1 | 8.14 |
| CHEMBL4100691 | — | — | 1 | 8.09 |
| CHEMBL4072262 | — | — | 1 | 8.07 |
| CHEMBL4076786 | — | — | 1 | 8.06 |
| CHEMBL4103808 | — | — | 1 | 8.04 |
| CHEMBL4075417 | — | — | 1 | 8.00 |
| CHEMBL4076639 | — | — | 1 | 7.99 |
| CHEMBL4075697 | — | — | 1 | 7.97 |
| CHEMBL4075762 | — | — | 1 | 7.97 |
| CHEMBL4089955 | — | — | 1 | 7.94 |
| CHEMBL4067290 | — | — | 1 | 7.91 |
| CHEMBL4074421 | — | — | 1 | 7.90 |
| CHEMBL4089416 | — | — | 1 | 7.90 |
| CHEMBL4075258 | — | — | 1 | 7.82 |
| CHEMBL4072134 | — | — | 1 | 7.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4074664 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL4087196 | — | Kd | = | 1.1 | nM | 8.96 |
| CHEMBL4073628 | — | Kd | = | 1.2 | nM | 8.92 |
| CHEMBL4063313 | — | Kd | = | 1.5 | nM | 8.82 |
| CHEMBL4093657 | — | Kd | = | 2.0 | nM | 8.70 |
| CHEMBL4067298 | — | Kd | = | 2.1 | nM | 8.68 |
| CHEMBL4088239 | — | Kd | = | 2.2 | nM | 8.66 |
| CHEMBL4080973 | — | Kd | = | 2.5 | nM | 8.60 |
| CHEMBL4091370 | — | Kd | = | 2.9 | nM | 8.54 |
| CHEMBL4077609 | — | Kd | = | 3.0 | nM | 8.52 |
| CHEMBL4104081 | — | Kd | = | 3.0 | nM | 8.52 |
| CHEMBL4093792 | — | Kd | = | 3.3 | nM | 8.48 |
| CHEMBL4067421 | — | Kd | = | 3.4 | nM | 8.47 |
| CHEMBL4064589 | — | Kd | = | 3.8 | nM | 8.42 |
| CHEMBL4060306 | — | Kd | = | 6.1 | nM | 8.21 |
| CHEMBL4101354 | — | Kd | = | 7.3 | nM | 8.14 |
| CHEMBL4100691 | — | Kd | = | 8.1 | nM | 8.09 |
| CHEMBL4072262 | — | Kd | = | 8.6 | nM | 8.07 |
| CHEMBL4076786 | — | Kd | = | 8.7 | nM | 8.06 |
| CHEMBL4103808 | — | Kd | = | 9.2 | nM | 8.04 |
| CHEMBL4075417 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL4076639 | — | Kd | = | 10.3 | nM | 7.99 |
| CHEMBL4075697 | — | Kd | = | 10.7 | nM | 7.97 |
| CHEMBL4075762 | — | Kd | = | 10.8 | nM | 7.97 |
| CHEMBL4089955 | — | Kd | = | 11.5 | nM | 7.94 |
| CHEMBL4067290 | — | Kd | = | 12.3 | nM | 7.91 |
| CHEMBL4074421 | — | Kd | = | 12.7 | nM | 7.90 |
| CHEMBL4089416 | — | Kd | = | 12.7 | nM | 7.90 |
| CHEMBL4075258 | — | Kd | = | 15.3 | nM | 7.82 |
| CHEMBL4072134 | — | Kd | = | 15.6 | nM | 7.81 |
| CHEMBL4075537 | — | Kd | = | 16.0 | nM | 7.80 |
| CHEMBL4081244 | — | Kd | = | 16.6 | nM | 7.78 |
| CHEMBL4066051 | — | Kd | = | 17.4 | nM | 7.76 |
| CHEMBL4092275 | — | Kd | = | 19.5 | nM | 7.71 |
| CHEMBL4062535 | — | Kd | = | 20.3 | nM | 7.69 |
| CHEMBL4085882 | — | Kd | = | 23.3 | nM | 7.63 |
| CHEMBL4089612 | — | Kd | = | 25.2 | nM | 7.60 |
| CHEMBL4088960 | — | Kd | = | 28.1 | nM | 7.55 |
| CHEMBL4093620 | — | Kd | = | 37.6 | nM | 7.42 |
| CHEMBL4075593 | — | Kd | = | 42.7 | nM | 7.37 |
| CHEMBL3337510 | — | Kd | = | 51.0 | nM | 7.29 |
| CHEMBL4076286 | — | Kd | = | 54.0 | nM | 7.27 |
| CHEMBL4092105 | — | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL593013 | — | Kd | = | 190.0 | nM | 6.72 |
| CHEMBL3937907 | — | Kd | = | 600.0 | nM | 6.22 |