Compound Detail
CHEMBL4064589
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL4064589 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XQCCADHVKCTQDD-UHFFFAOYSA-N |
1
Targets
4
Activities
3
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
450.9
MW (Da)
5.61
ALogP
5
HBA
1
HBD
51.5
PSA (Ų)
0.55
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 7.73
Kd 1 meas. best 8.42
Ki 1 meas. best 8.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 2 CHEMBL5137 | Kd | 8.42 | 8.42 | 3.8 | 1 |
| Metabotropic glutamate receptor 2 CHEMBL5137 | Ki | 8.3 | 8.3 | 5.0 | 1 |
| Metabotropic glutamate receptor 2 CHEMBL5137 | EC50 | 7.73 | 7.73 | 18.6 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 2 | Kd | = | 3.8 | nM | 8.42 | Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 c... | 28704052 |
| Metabotropic glutamate receptor 2 | Ki | = | 5.012 | nM | 8.3 | Displacement of [3H]-JNJ46281222 from human metabotropic glutamate receptor 2 ex... | 28704052 |
| Metabotropic glutamate receptor 2 | EC50 | = | 18.62 | nM | 7.73 | Positive allosteric modulation of human metabotropic glutamate receptor 2 expres... | 28704052 |
| Metabotropic glutamate receptor 2 | EC50 | = | 18.62 | nM | 7.73 | Positive allosteric modulation of human metabotropic glutamate receptor 2 expres... | 28704052 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28704052 | 10.1021/acs.jmedchem.7b00669 | Metabotropic glutamate receptor 2 | 9 |
Data from ChEMBL 36 via Core Engine