Assay Detail
Binding
CHEMBL4040574
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of glycosylated human ATX using FS-3 as substrate preincubated for 30 mins followed by substrate addition measured after 30 mins by fluorescence assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.94 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4100462 | — | — | 1 | 8.70 |
| CHEMBL4073638 | — | — | 1 | 8.30 |
| CHEMBL4084005 | — | — | 1 | 8.10 |
| CHEMBL4062291 | — | — | 1 | 8.05 |
| CHEMBL4091774 | — | — | 1 | 7.92 |
| CHEMBL4061747 | — | — | 1 | 7.57 |
| CHEMBL4084750 | — | — | 1 | 6.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4100462 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4073638 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4084005 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4062291 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4091774 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4061747 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4084750 | — | IC50 | = | 122.0 | nM | 6.91 |