Assay Detail
Binding
CHEMBL4041119
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human cathepsin L using Cbz-Phe-Arg-AMC as substrate after 10 mins by fluorescence assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.58 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4078345 | — | — | 1 | 9.40 |
| CHEMBL4083754 | — | — | 1 | 9.21 |
| CHEMBL4062015 | — | — | 1 | 8.66 |
| CHEMBL4096388 | — | — | 1 | 8.46 |
| CHEMBL4093034 | — | — | 1 | 7.60 |
| CHEMBL4082758 | — | — | 1 | 7.57 |
| CHEMBL374508 | E-64 | — | 1 | 7.52 |
| CHEMBL4101714 | — | — | 1 | 7.40 |
| CHEMBL4100751 | — | — | 1 | 7.39 |
| CHEMBL4081250 | — | — | 1 | 7.35 |
| CHEMBL4072275 | — | — | 1 | 6.96 |
| CHEMBL4060936 | — | — | 1 | 6.62 |
| CHEMBL4070637 | — | — | 1 | 6.60 |
| CHEMBL2402204 | — | — | 1 | 6.54 |
| CHEMBL4099269 | — | — | 1 | 6.48 |
| CHEMBL4090306 | — | — | 1 | - |
| CHEMBL4074432 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4078345 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL4083754 | — | Ki | = | 0.61 | nM | 9.21 |
| CHEMBL4062015 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL4096388 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL4093034 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL4082758 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL374508 | E-64 | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL4101714 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL4100751 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL4081250 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL4072275 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL4060936 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL4070637 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL2402204 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL4099269 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL4090306 | — | Ki | - | — | - | |
| CHEMBL4074432 | — | Ki | - | — | - |