Assay Detail
Functional
CHEMBL4041122
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiparasitic activity against bloodstream form of Trypanosoma brucei brucei 449 after 24 hrs by ATPlite assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.22 | 6.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL790 | CHLORHEXIDINE | 4.0 | 1 | 6.17 |
| CHEMBL4083754 | — | — | 1 | 5.60 |
| CHEMBL4078345 | — | — | 1 | 5.50 |
| CHEMBL4096388 | — | — | 1 | 5.49 |
| CHEMBL4072275 | — | — | 1 | 5.42 |
| CHEMBL4081250 | — | — | 1 | 5.26 |
| CHEMBL4101714 | — | — | 1 | 5.22 |
| CHEMBL4062015 | — | — | 1 | 5.22 |
| CHEMBL4082758 | — | — | 1 | 4.89 |
| CHEMBL2402204 | — | — | 1 | 4.62 |
| CHEMBL4093034 | — | — | 1 | 4.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL790 | CHLORHEXIDINE | EC50 | = | 670.0 | nM | 6.17 |
| CHEMBL4083754 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4078345 | — | EC50 | = | 3180.0 | nM | 5.50 |
| CHEMBL4096388 | — | EC50 | = | 3230.0 | nM | 5.49 |
| CHEMBL4072275 | — | EC50 | = | 3850.0 | nM | 5.42 |
| CHEMBL4081250 | — | EC50 | = | 5480.0 | nM | 5.26 |
| CHEMBL4101714 | — | EC50 | = | 6080.0 | nM | 5.22 |
| CHEMBL4062015 | — | EC50 | = | 6050.0 | nM | 5.22 |
| CHEMBL4082758 | — | EC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL2402204 | — | EC50 | = | 23700.0 | nM | 4.62 |
| CHEMBL4093034 | — | EC50 | = | 97200.0 | nM | 4.01 |