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Assay Detail

CHEMBL4041253

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HepG2
Confidence 1 — Organism
Curated By Autocuration

Target

HepG2 (CHEMBL395)
Type CELL-LINE
Organism Homo sapiens

Publication

Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Isocombretastatins and Phenstatins as Antitumor Agents.
Pang Y, An B, Lou L, Zhang J, Yan J, Huang L, Li X, Yin S.
J Med Chem (2017) 60 : 7300 -7314
PubMed 28792756 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 6.64 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4089545 1 8.52
CHEMBL67 COMBRETASTATIN A4 -1.0 1 8.41
CHEMBL498271 1 7.74
CHEMBL4073832 1 7.51
CHEMBL4100632 1 7.33
CHEMBL4075698 1 7.11
CHEMBL4103099 1 7.07
CHEMBL4078010 1 7.06
CHEMBL276625 PHENSTATIN 1 6.97
CHEMBL4088329 1 6.90
CHEMBL4092897 1 6.54
CHEMBL4096056 1 6.53
CHEMBL4061326 1 6.41
CHEMBL4076223 1 6.33
CHEMBL4103810 1 6.22
CHEMBL4062481 1 6.18
CHEMBL4067059 1 6.16
CHEMBL4065238 1 5.96
CHEMBL4085885 1 5.87
CHEMBL4084181 1 5.81
CHEMBL4061396 1 5.64
CHEMBL4085156 1 5.36
CHEMBL4072461 1 5.20

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4089545 IC50 = 3.0 nM 8.52
CHEMBL67 COMBRETASTATIN A4 IC50 = 3.9 nM 8.41
CHEMBL498271 IC50 = 18.3 nM 7.74
CHEMBL4073832 IC50 = 31.0 nM 7.51
CHEMBL4100632 IC50 = 47.0 nM 7.33
CHEMBL4075698 IC50 = 77.0 nM 7.11
CHEMBL4103099 IC50 = 85.0 nM 7.07
CHEMBL4078010 IC50 = 87.0 nM 7.06
CHEMBL276625 PHENSTATIN IC50 = 108.0 nM 6.97
CHEMBL4088329 IC50 = 126.0 nM 6.90
CHEMBL4092897 IC50 = 288.0 nM 6.54
CHEMBL4096056 IC50 = 298.0 nM 6.53
CHEMBL4061326 IC50 = 386.0 nM 6.41
CHEMBL4076223 IC50 = 473.0 nM 6.33
CHEMBL4103810 IC50 = 607.0 nM 6.22
CHEMBL4062481 IC50 = 655.0 nM 6.18
CHEMBL4067059 IC50 = 691.0 nM 6.16
CHEMBL4065238 IC50 = 1086.0 nM 5.96
CHEMBL4085885 IC50 = 1350.0 nM 5.87
CHEMBL4084181 IC50 = 1534.0 nM 5.81
CHEMBL4061396 IC50 = 2296.0 nM 5.64
CHEMBL4085156 IC50 = 4338.0 nM 5.36
CHEMBL4072461 IC50 = 6299.0 nM 5.20