Compound Detail
CHEMBL4088329
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Basic Information
| ChEMBL ID | CHEMBL4088329 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GIELHOKNCLDCCR-UHFFFAOYSA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
363.3
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 7.14
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| A549 CHEMBL392 | IC50 | 7.14 | 7.14 | 72.0 | 1 |
| LoVo CHEMBL614721 | IC50 | 7.04 | 7.04 | 91.0 | 1 |
| MDA-MB-231 CHEMBL400 | IC50 | 7.02 | 7.02 | 96.0 | 1 |
| RKO CHEMBL614879 | IC50 | 6.97 | 6.97 | 107.0 | 1 |
| HepG2 CHEMBL395 | IC50 | 6.9 | 6.9 | 126.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| A549 | IC50 | = | 72.0 | nM | 7.14 | Antiproliferative activity against human A549 cells after 48 hrs by MTT assay | 28792756 |
| LoVo | IC50 | = | 91.0 | nM | 7.04 | Antiproliferative activity against human LoVo cells after 48 hrs by MTT assay | 28792756 |
| MDA-MB-231 | IC50 | = | 96.0 | nM | 7.02 | Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT as... | 28792756 |
| RKO | IC50 | = | 107.0 | nM | 6.97 | Antiproliferative activity against human RKO cells after 48 hrs by MTT assay | 28792756 |
| HepG2 | IC50 | = | 126.0 | nM | 6.9 | Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay | 28792756 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28792756 | 10.1021/acs.jmedchem.7b00480 | MDA-MB-231 | 1 |
| 28792756 | 10.1021/acs.jmedchem.7b00480 | HepG2 | 1 |
| 28792756 | 10.1021/acs.jmedchem.7b00480 | LoVo | 1 |
| 28792756 | 10.1021/acs.jmedchem.7b00480 | RKO | 1 |
| 28792756 | 10.1021/acs.jmedchem.7b00480 | A549 | 1 |
Data from ChEMBL 36 via Core Engine