Assay Detail
Binding
CHEMBL4041378
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Inhibition of human HGPRT using PRib-PP as the substrate by spectrophotometric method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Hypoxanthine-guanine phosphoribosyltransferase (CHEMBL2360) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and Evaluation of Asymmetric Acyclic Nucleoside Bisphosphonates as Inhibitors of Plasmodium falciparum and Human Hypoxanthine-Guanine-(Xanthine) Phosphoribosyltransferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.37 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4086362 | — | — | 1 | 8.22 |
| CHEMBL4067618 | — | — | 1 | 7.00 |
| CHEMBL4078513 | — | — | 1 | 7.00 |
| CHEMBL4064903 | — | — | 1 | 6.40 |
| CHEMBL2325754 | — | — | 1 | 6.22 |
| CHEMBL3578109 | — | — | 1 | 6.16 |
| CHEMBL2325753 | — | — | 1 | 6.00 |
| CHEMBL4102796 | — | — | 1 | 5.75 |
| CHEMBL4083808 | — | — | 1 | 5.60 |
| CHEMBL4066772 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4086362 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL4067618 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL4078513 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL4064903 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL2325754 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL3578109 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL2325753 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL4102796 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL4083808 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL4066772 | — | Ki | = | 4600.0 | nM | 5.34 |