Assay Detail
Binding
CHEMBL4041927
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Antagonist activity at H3 receptor (unknown origin)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of nanomolar ligands with novel scaffolds for the histamine H4 receptor by virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.58 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4084820 | — | — | 1 | 8.32 |
| CHEMBL4063170 | — | — | 1 | 8.08 |
| CHEMBL4102970 | — | — | 1 | 8.02 |
| CHEMBL4065099 | — | — | 1 | 7.85 |
| CHEMBL4062122 | — | — | 1 | 7.66 |
| CHEMBL1179089 | — | — | 1 | 7.62 |
| CHEMBL20338 | — | — | 1 | 7.39 |
| CHEMBL4098585 | — | — | 1 | 7.33 |
| CHEMBL4100315 | — | — | 1 | 6.93 |
| CHEMBL4095224 | — | — | 1 | 6.59 |
| CHEMBL91576 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4084820 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL4063170 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL4102970 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL4065099 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL4062122 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL1179089 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL20338 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL4098585 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL4100315 | — | Ki | = | 118.0 | nM | 6.93 |
| CHEMBL4095224 | — | Ki | = | 258.0 | nM | 6.59 |
| CHEMBL91576 | — | Ki | > | 1000.0 | nM | - |