Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4041955

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of M-phase starfish oocytes CDK1/cyclin B after 30 mins by [gamma-33P]ATP based scintillation counting analysis
ChEMBL ↗
60
Total Activities
60
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Asteroidea
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Exploration of the imidazo[1,2-b]pyridazine scaffold as a protein kinase inhibitor.
Bendjeddou LZ, Loaëc N, Villiers B, Prina E, Späth GF, Galons H, Meijer L, Oumata N.
Eur J Med Chem (2017) 125 : 696 -709
PubMed 27721154 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 60 5.72 7.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4061526 — — 1 7.15
CHEMBL4102871 — — 1 6.77
CHEMBL4070189 — — 1 6.57
CHEMBL4071322 — — 1 6.44
CHEMBL4089652 — — 1 6.29
CHEMBL4092673 — — 1 6.28
CHEMBL4070227 — — 1 6.23
CHEMBL4065432 — — 1 6.15
CHEMBL4093104 — — 1 6.12
CHEMBL4097368 — — 1 6.10
CHEMBL4074499 — — 1 6.05
CHEMBL4072506 — — 1 5.96
CHEMBL4105084 — — 1 5.96
CHEMBL4086402 — — 1 5.89
CHEMBL4069158 — — 1 5.85
CHEMBL4082981 — — 1 5.77
CHEMBL4104296 — — 1 5.77
CHEMBL4062820 — — 1 5.75
CHEMBL4074132 — — 1 5.64
CHEMBL4090770 — — 1 5.57
CHEMBL4090223 — — 1 5.57
CHEMBL4092047 — — 1 5.55
CHEMBL4100956 — — 1 5.52
CHEMBL4067477 — — 1 5.50
CHEMBL4098107 — — 1 5.48
CHEMBL4091942 — — 1 5.39
CHEMBL4084364 — — 1 5.39
CHEMBL4079347 — — 1 5.37
CHEMBL4087260 — — 1 5.29
CHEMBL4063254 — — 1 5.29

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4061526 — IC50 = 71.0 nM 7.15
CHEMBL4102871 — IC50 = 170.0 nM 6.77
CHEMBL4070189 — IC50 = 270.0 nM 6.57
CHEMBL4071322 — IC50 = 360.0 nM 6.44
CHEMBL4089652 — IC50 = 510.0 nM 6.29
CHEMBL4092673 — IC50 = 520.0 nM 6.28
CHEMBL4070227 — IC50 = 590.0 nM 6.23
CHEMBL4065432 — IC50 = 710.0 nM 6.15
CHEMBL4093104 — IC50 = 760.0 nM 6.12
CHEMBL4097368 — IC50 = 800.0 nM 6.10
CHEMBL4074499 — IC50 = 890.0 nM 6.05
CHEMBL4072506 — IC50 = 1100.0 nM 5.96
CHEMBL4105084 — IC50 = 1100.0 nM 5.96
CHEMBL4086402 — IC50 = 1300.0 nM 5.89
CHEMBL4069158 — IC50 = 1400.0 nM 5.85
CHEMBL4082981 — IC50 = 1700.0 nM 5.77
CHEMBL4104296 — IC50 = 1700.0 nM 5.77
CHEMBL4062820 — IC50 = 1800.0 nM 5.75
CHEMBL4074132 — IC50 = 2300.0 nM 5.64
CHEMBL4090770 — IC50 = 2700.0 nM 5.57
CHEMBL4090223 — IC50 = 2700.0 nM 5.57
CHEMBL4092047 — IC50 = 2800.0 nM 5.55
CHEMBL4100956 — IC50 = 3000.0 nM 5.52
CHEMBL4067477 — IC50 = 3200.0 nM 5.50
CHEMBL4098107 — IC50 = 3300.0 nM 5.48
CHEMBL4091942 — IC50 = 4100.0 nM 5.39
CHEMBL4084364 — IC50 = 4100.0 nM 5.39
CHEMBL4079347 — IC50 = 4300.0 nM 5.37
CHEMBL4087260 — IC50 = 5100.0 nM 5.29
CHEMBL4063254 — IC50 = 5100.0 nM 5.29
CHEMBL4084919 — IC50 = 5300.0 nM 5.28
CHEMBL4071413 — IC50 = 5400.0 nM 5.27
CHEMBL4093231 — IC50 = 6100.0 nM 5.21
CHEMBL4088717 — IC50 = 6100.0 nM 5.21
CHEMBL4061394 — IC50 = 6700.0 nM 5.17
CHEMBL4070065 — IC50 = 7500.0 nM 5.12
CHEMBL4076448 — IC50 = 7900.0 nM 5.10
CHEMBL4077125 — IC50 = 7900.0 nM 5.10
CHEMBL4071013 — IC50 = 8200.0 nM 5.09
CHEMBL4062683 — IC50 > 10000.0 nM -
CHEMBL4091127 — IC50 > 10000.0 nM -
CHEMBL4076663 — IC50 > 10000.0 nM -
CHEMBL4079343 — IC50 > 10000.0 nM -
CHEMBL4067420 — IC50 > 10000.0 nM -
CHEMBL4062568 — IC50 > 10000.0 nM -
CHEMBL4064988 — IC50 > 10000.0 nM -
CHEMBL4075509 — IC50 > 10000.0 nM -
CHEMBL4083948 — IC50 > 10000.0 nM -
CHEMBL4098237 — IC50 > 10000.0 nM -
CHEMBL4092117 — IC50 > 10000.0 nM -