Compound Detail
CHEMBL4062568
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Basic Information
| ChEMBL ID | CHEMBL4062568 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DRJPJGLJJAOLKO-UHFFFAOYSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
14
Publications
0
Known Names
Molecular Properties
289.3
MW (Da)
0.93
ALogP
7
HBA
0
HBD
88.3
PSA (Ų)
0.53
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 5.75
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dual specificity protein kinase CLK4 CHEMBL1075283 | IC50 | 5.75 | 5.75 | 1800.0 | 1 |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A CHEMBL2292 | IC50 | 5.29 | 5.29 | 5100.0 | 1 |
| Dual specificity protein kinase CLK1 CHEMBL1075280 | IC50 | 5.26 | 5.26 | 5500.0 | 1 |
| Dual specificity protein kinase CLK2 CHEMBL1075281 | IC50 | 5.09 | 5.09 | 8200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dual specificity protein kinase CLK4 | IC50 | = | 1800.0 | nM | 5.75 | Inhibition of GST tagged recombinant mouse CLK4 expressed in Escherichia coli us... | 27721154 |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | IC50 | = | 5100.0 | nM | 5.29 | Inhibition of GST tagged recombinant human DYRK1A expressed in Escherichia coli ... | 27721154 |
| Dual specificity protein kinase CLK1 | IC50 | = | 5500.0 | nM | 5.26 | Inhibition of GST tagged recombinant mouse CLK1 expressed in Escherichia coli us... | 27721154 |
| Dual specificity protein kinase CLK2 | IC50 | = | 8200.0 | nM | 5.09 | Inhibition of GST tagged recombinant mouse CLK2 expressed in Escherichia coli us... | 27721154 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27721154 | 10.1016/j.ejmech.2016.09.064 | Unchecked | 14 |
| 27721154 | 10.1016/j.ejmech.2016.09.064 | Leishmania amazonensis | 3 |
| 27721154 | 10.1016/j.ejmech.2016.09.064 | SH-SY5Y | 2 |
| 27721154 | 10.1016/j.ejmech.2016.09.064 | CDK2/Cyclin A2 | 1 |
| 27721154 | 10.1016/j.ejmech.2016.09.064 | Cyclin-dependent kinase 5/CDK5 activator 1 | 1 |
| 27721154 | 10.1016/j.ejmech.2016.09.064 | CDK9/cyclin T1 | 1 |
| 27721154 | 10.1016/j.ejmech.2016.09.064 | Dual specificity protein kinase CLK1 | 1 |
| 27721154 | 10.1016/j.ejmech.2016.09.064 | Dual specificity protein kinase CLK2 | 1 |
| 27721154 | 10.1016/j.ejmech.2016.09.064 | Dual specificity protein kinase CLK3 | 1 |
| 27721154 | 10.1016/j.ejmech.2016.09.064 | Dual specificity protein kinase CLK4 | 1 |
| 27721154 | 10.1016/j.ejmech.2016.09.064 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 1 |
| 27721154 | 10.1016/j.ejmech.2016.09.064 | Dual specificity tyrosine-phosphorylation-regulated kinase 1B | 1 |
| 27721154 | 10.1016/j.ejmech.2016.09.064 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | 1 |
| 27721154 | 10.1016/j.ejmech.2016.09.064 | Dual specificity tyrosine-phosphorylation-regulated kinase 3 | 1 |
Data from ChEMBL 36 via Core Engine