Assay Detail
Binding
CHEMBL4041957
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Inhibition of human recombinant CDK5/p25 after 30 mins by [gamma-33P]ATP based scintillation counting analysis
60
Total Activities
60
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 5/CDK5 activator 1 (CHEMBL1907600) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Exploration of the imidazo[1,2-b]pyridazine scaffold as a protein kinase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 60 | 5.61 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4061526 | — | — | 1 | 6.72 |
| CHEMBL4102871 | — | — | 1 | 6.66 |
| CHEMBL4074499 | — | — | 1 | 6.41 |
| CHEMBL4093104 | — | — | 1 | 6.32 |
| CHEMBL4070227 | — | — | 1 | 6.23 |
| CHEMBL4097368 | — | — | 1 | 6.23 |
| CHEMBL4105084 | — | — | 1 | 6.21 |
| CHEMBL4069158 | — | — | 1 | 6.12 |
| CHEMBL4076448 | — | — | 1 | 6.09 |
| CHEMBL4089652 | — | — | 1 | 6.09 |
| CHEMBL4070189 | — | — | 1 | 6.05 |
| CHEMBL4065432 | — | — | 1 | 6.00 |
| CHEMBL4092673 | — | — | 1 | 5.96 |
| CHEMBL4071322 | — | — | 1 | 5.96 |
| CHEMBL4062820 | — | — | 1 | 5.92 |
| CHEMBL4074132 | — | — | 1 | 5.85 |
| CHEMBL4100956 | — | — | 1 | 5.77 |
| CHEMBL4072506 | — | — | 1 | 5.75 |
| CHEMBL4092047 | — | — | 1 | 5.66 |
| CHEMBL4090770 | — | — | 1 | 5.51 |
| CHEMBL4088717 | — | — | 1 | 5.42 |
| CHEMBL4090223 | — | — | 1 | 5.38 |
| CHEMBL4076906 | — | — | 1 | 5.33 |
| CHEMBL4070065 | — | — | 1 | 5.33 |
| CHEMBL4079347 | — | — | 1 | 5.29 |
| CHEMBL4084364 | — | — | 1 | 5.29 |
| CHEMBL4071413 | — | — | 1 | 5.21 |
| CHEMBL4091942 | — | — | 1 | 5.17 |
| CHEMBL4061394 | — | — | 1 | 5.17 |
| CHEMBL4104296 | — | — | 1 | 5.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4061526 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4102871 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4074499 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4093104 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4070227 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL4097368 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL4105084 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL4069158 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL4076448 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4089652 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4070189 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL4065432 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4071322 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4092673 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4062820 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4074132 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4100956 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4072506 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4092047 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4090770 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4088717 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4090223 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4076906 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4070065 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4084364 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4079347 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4071413 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL4091942 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4061394 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4104296 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL4082981 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL4067477 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4098107 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4089542 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL4086402 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL4087260 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL4098237 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4083948 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4075509 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4071013 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4064988 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4091127 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4067420 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4062568 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4077125 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4063254 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4079343 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4062683 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4084919 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4076663 | — | IC50 | > | 10000.0 | nM | - |