Assay Detail
Binding
CHEMBL4041969
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Inhibition of recombinant Leishmania donovani DYRK3 expressed in Escherichia coli using woodtide as substrate after 30 mins in presence of [gamma-33P]ATP by liquid scintillation counting
61
Total Activities
61
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Leishmania donovani |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Exploration of the imidazo[1,2-b]pyridazine scaffold as a protein kinase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 61 | 5.42 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4089652 | — | — | 1 | 6.38 |
| CHEMBL4061526 | — | — | 1 | 5.96 |
| CHEMBL4071322 | — | — | 1 | 5.89 |
| CHEMBL4080844 | — | — | 1 | 5.66 |
| CHEMBL4070227 | — | — | 1 | 5.51 |
| CHEMBL4065432 | — | — | 1 | 5.48 |
| CHEMBL4070189 | — | — | 1 | 5.48 |
| CHEMBL4084919 | — | — | 1 | 5.42 |
| CHEMBL4093104 | — | — | 1 | 5.32 |
| CHEMBL4072506 | — | — | 1 | 5.22 |
| CHEMBL4091127 | — | — | 1 | 5.19 |
| CHEMBL4102871 | — | — | 1 | 5.16 |
| CHEMBL4093231 | — | — | 1 | 5.07 |
| CHEMBL4079347 | — | — | 1 | 5.04 |
| CHEMBL4082981 | — | — | 1 | 5.00 |
| CHEMBL4062820 | — | — | 1 | 5.00 |
| CHEMBL4063254 | — | — | 1 | - |
| CHEMBL1802358 | — | — | 1 | - |
| CHEMBL4069158 | — | — | 1 | - |
| CHEMBL4090223 | — | — | 1 | - |
| CHEMBL4077125 | — | — | 1 | - |
| CHEMBL4071413 | — | — | 1 | - |
| CHEMBL4098237 | — | — | 1 | - |
| CHEMBL4074132 | — | — | 1 | - |
| CHEMBL4083948 | — | — | 1 | - |
| CHEMBL4075509 | — | — | 1 | - |
| CHEMBL4062568 | — | — | 1 | - |
| CHEMBL4067420 | — | — | 1 | - |
| CHEMBL4074499 | — | — | 1 | - |
| CHEMBL4071013 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4089652 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4061526 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4071322 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4080844 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4070227 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4065432 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4070189 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4084919 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4093104 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4072506 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4091127 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL4102871 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4093231 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL4079347 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL4062820 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4082981 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4062683 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4076663 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4079343 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4090770 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4081668 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4091942 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4076906 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4070065 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4097256 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4061394 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4089542 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4087260 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4076448 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4077159 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4075820 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4085467 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4092117 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4083948 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4063254 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1802358 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4069158 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4090223 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4077125 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4071413 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4098237 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4074132 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4092673 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4075509 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4062568 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4067420 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4074499 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4071013 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4064988 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4098107 | — | IC50 | > | 10000.0 | nM | - |