Assay Detail
Binding
CHEMBL4042008
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Inhibition of recombinant ABL1 (unknown origin) after 120 mins in presence of [33P]ATP
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Natural-Based Indirubins Display Potent Cytotoxicity toward Wild-Type and T315I-Resistant Leukemia Cell Lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.32 | 9.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3216659 | — | — | 1 | 9.06 |
| CHEMBL494867 | — | — | 1 | 8.14 |
| CHEMBL495306 | — | — | 1 | 7.99 |
| CHEMBL493657 | — | — | 1 | 7.47 |
| CHEMBL493883 | — | — | 1 | 7.17 |
| CHEMBL494685 | — | — | 1 | 6.97 |
| CHEMBL493656 | — | — | 1 | 6.33 |
| CHEMBL3215571 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3216659 | — | IC50 | = | 0.87 | nM | 9.06 |
| CHEMBL494867 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL495306 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL493657 | — | IC50 | = | 34.1 | nM | 7.47 |
| CHEMBL493883 | — | IC50 | = | 66.9 | nM | 7.17 |
| CHEMBL494685 | — | IC50 | = | 106.5 | nM | 6.97 |
| CHEMBL493656 | — | IC50 | = | 468.0 | nM | 6.33 |
| CHEMBL3215571 | — | IC50 | = | 3440.0 | nM | 5.46 |