Assay Detail
Functional
CHEMBL4042089
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Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by alamar blue assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antibacterial and Cytotoxic Actinomycins Y6-Y9 and Zp from Streptomyces sp. Strain Gö-GS12.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 8.53 | 9.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4094032 | — | — | 1 | 9.87 |
| CHEMBL1554 | DACTINOMYCIN | 4.0 | 1 | 9.70 |
| CHEMBL4073381 | — | — | 1 | 9.13 |
| CHEMBL4099462 | — | — | 1 | 8.81 |
| CHEMBL4073368 | — | — | 1 | 8.12 |
| CHEMBL4080332 | — | — | 1 | 7.15 |
| CHEMBL4098358 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4094032 | — | EC50 | = | 0.135 | nM | 9.87 |
| CHEMBL1554 | DACTINOMYCIN | EC50 | = | 0.201 | nM | 9.70 |
| CHEMBL4073381 | — | EC50 | = | 0.74 | nM | 9.13 |
| CHEMBL4099462 | — | EC50 | = | 1.54 | nM | 8.81 |
| CHEMBL4073368 | — | EC50 | = | 7.67 | nM | 8.12 |
| CHEMBL4080332 | — | EC50 | = | 71.48 | nM | 7.15 |
| CHEMBL4098358 | — | EC50 | = | 119.3 | nM | 6.92 |