Compound Detail
CHEMBL4080332
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5[C@H](C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)[C@@H](O)C[C@@H]5C)c3nc-2c2c(c1=O)N[C@H]([C@@H]1NC(=O)[C@H](C)N(C)C(=O)CN(C)C(=O)[C@@H]3CC(=O)CN3C(=O)[C@@H](C(C)C)NC1=O)COC2=O
Basic Information
| ChEMBL ID | CHEMBL4080332 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KLFMLKUJSQSQEM-SDCBHFABSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
9
Publications
0
Known Names
Molecular Properties
1269.4
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 7.15
Target Activity Profile
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| A549 | EC50 | = | 71.48 | nM | 7.15 | Cytotoxicity against human A549 cells assessed as reduction in cell viability af... | 27736087 |
| PC-3 | EC50 | = | 76.7 | nM | 7.12 | Cytotoxicity against human PC3 cells assessed as reduction in cell viability aft... | 27736087 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27736087 | 10.1021/acs.jnatprod.6b00742 | Staphylococcus aureus | 1 |
| 27736087 | 10.1021/acs.jnatprod.6b00742 | Micrococcus luteus | 1 |
| 27736087 | 10.1021/acs.jnatprod.6b00742 | Bacillus spizizenii | 1 |
| 27736087 | 10.1021/acs.jnatprod.6b00742 | Mycolicibacterium aurum | 1 |
| 27736087 | 10.1021/acs.jnatprod.6b00742 | Unchecked | 1 |
| 27736087 | 10.1021/acs.jnatprod.6b00742 | Escherichia coli | 1 |
| 27736087 | 10.1021/acs.jnatprod.6b00742 | Saccharomyces cerevisiae | 1 |
| 27736087 | 10.1021/acs.jnatprod.6b00742 | PC-3 | 1 |
| 27736087 | 10.1021/acs.jnatprod.6b00742 | A549 | 1 |
Data from ChEMBL 36 via Core Engine