Assay Detail
Functional
CHEMBL4042170
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Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Urea-containing peptide boronic acids as potent proteasome inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.28 | 8.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.79 |
| CHEMBL4089402 | — | — | 1 | 8.08 |
| CHEMBL4100727 | — | — | 1 | 7.72 |
| CHEMBL4095083 | — | — | 1 | 7.59 |
| CHEMBL4068221 | — | — | 1 | 7.52 |
| CHEMBL4080306 | — | — | 1 | 7.43 |
| CHEMBL4070336 | — | — | 1 | 7.43 |
| CHEMBL4076838 | — | — | 1 | 7.36 |
| CHEMBL4077037 | — | — | 1 | 7.35 |
| CHEMBL4096371 | — | — | 1 | 7.34 |
| CHEMBL4075225 | — | — | 1 | 7.28 |
| CHEMBL4105585 | — | — | 1 | 7.22 |
| CHEMBL4091983 | — | — | 1 | 7.15 |
| CHEMBL4077282 | — | — | 1 | 7.15 |
| CHEMBL484701 | — | — | 1 | 7.06 |
| CHEMBL4075298 | — | — | 1 | 5.97 |
| CHEMBL4065491 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 1.61 | nM | 8.79 |
| CHEMBL4089402 | — | IC50 | = | 8.38 | nM | 8.08 |
| CHEMBL4100727 | — | IC50 | = | 19.04 | nM | 7.72 |
| CHEMBL4095083 | — | IC50 | = | 25.96 | nM | 7.59 |
| CHEMBL4068221 | — | IC50 | = | 30.49 | nM | 7.52 |
| CHEMBL4080306 | — | IC50 | = | 36.99 | nM | 7.43 |
| CHEMBL4070336 | — | IC50 | = | 37.25 | nM | 7.43 |
| CHEMBL4076838 | — | IC50 | = | 43.81 | nM | 7.36 |
| CHEMBL4077037 | — | IC50 | = | 44.68 | nM | 7.35 |
| CHEMBL4096371 | — | IC50 | = | 45.6 | nM | 7.34 |
| CHEMBL4075225 | — | IC50 | = | 53.08 | nM | 7.28 |
| CHEMBL4105585 | — | IC50 | = | 59.67 | nM | 7.22 |
| CHEMBL4091983 | — | IC50 | = | 70.67 | nM | 7.15 |
| CHEMBL4077282 | — | IC50 | = | 70.86 | nM | 7.15 |
| CHEMBL484701 | — | IC50 | = | 87.25 | nM | 7.06 |
| CHEMBL4075298 | — | IC50 | = | 1072.0 | nM | 5.97 |
| CHEMBL4065491 | — | IC50 | = | 4136.0 | nM | 5.38 |