Compound Detail
CHEMBL4065491
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Basic Information
| ChEMBL ID | CHEMBL4065491 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JZTQMQRUMQSZRC-ROUUACIJSA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
413.3
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 7.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Proteasome Macropain subunit MB1 CHEMBL4662 | IC50 | 7.3 | 7.3 | 50.0 | 1 |
| MGC-803 CHEMBL3706566 | IC50 | 6.13 | 6.13 | 738.2 | 1 |
| Proteasome component C5 CHEMBL4208 | IC50 | 6.1 | 6.1 | 790.0 | 1 |
| HepG2 CHEMBL395 | IC50 | 5.38 | 5.38 | 4136.0 | 1 |
| Proteasome Macropain subunit CHEMBL3492 | IC50 | 4.94 | 4.94 | 11400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Proteasome Macropain subunit MB1 | IC50 | = | 50.0 | nM | 7.3 | Inhibition of chymotrypsin-like activity of 20S proteasome in human HL60 cells u... | 27769033 |
| MGC-803 | IC50 | = | 738.2 | nM | 6.13 | Antiproliferative activity against human MGC803 cells after 72 hrs by MTT assay | 27769033 |
| Proteasome component C5 | IC50 | = | 790.0 | nM | 6.1 | Inhibition of caspase-like activity of 20S proteasome in human HL60 cells using ... | 27769033 |
| HepG2 | IC50 | = | 4136.0 | nM | 5.38 | Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay | 27769033 |
| Proteasome Macropain subunit | IC50 | = | 11400.0 | nM | 4.94 | Inhibition of trypsin-like activity of 20S proteasome in human HL60 cells using ... | 27769033 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27769033 | 10.1016/j.ejmech.2016.10.023 | Proteasome Macropain subunit MB1 | 1 |
| 27769033 | 10.1016/j.ejmech.2016.10.023 | HepG2 | 1 |
| 27769033 | 10.1016/j.ejmech.2016.10.023 | MGC-803 | 1 |
| 27769033 | 10.1016/j.ejmech.2016.10.023 | Proteasome Macropain subunit | 1 |
| 27769033 | 10.1016/j.ejmech.2016.10.023 | Proteasome component C5 | 1 |
Data from ChEMBL 36 via Core Engine