Assay Detail
Functional
CHEMBL4042171
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Antiproliferative activity against human MGC803 cells after 72 hrs by MTT assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MGC-803 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Urea-containing peptide boronic acids as potent proteasome inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.89 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4089402 | — | — | 1 | 8.40 |
| CHEMBL4080306 | — | — | 1 | 8.39 |
| CHEMBL4068221 | — | — | 1 | 8.28 |
| CHEMBL4096371 | — | — | 1 | 8.27 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.24 |
| CHEMBL4070336 | — | — | 1 | 8.23 |
| CHEMBL4077037 | — | — | 1 | 8.20 |
| CHEMBL4076838 | — | — | 1 | 8.20 |
| CHEMBL4100727 | — | — | 1 | 8.17 |
| CHEMBL4075225 | — | — | 1 | 8.15 |
| CHEMBL4105585 | — | — | 1 | 8.14 |
| CHEMBL4095083 | — | — | 1 | 7.76 |
| CHEMBL484701 | — | — | 1 | 7.73 |
| CHEMBL4091983 | — | — | 1 | 7.54 |
| CHEMBL4077282 | — | — | 1 | 7.52 |
| CHEMBL4075298 | — | — | 1 | 6.70 |
| CHEMBL4065491 | — | — | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4089402 | — | IC50 | = | 3.962 | nM | 8.40 |
| CHEMBL4080306 | — | IC50 | = | 4.084 | nM | 8.39 |
| CHEMBL4068221 | — | IC50 | = | 5.203 | nM | 8.28 |
| CHEMBL4096371 | — | IC50 | = | 5.316 | nM | 8.27 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 5.782 | nM | 8.24 |
| CHEMBL4070336 | — | IC50 | = | 5.873 | nM | 8.23 |
| CHEMBL4077037 | — | IC50 | = | 6.298 | nM | 8.20 |
| CHEMBL4076838 | — | IC50 | = | 6.317 | nM | 8.20 |
| CHEMBL4100727 | — | IC50 | = | 6.698 | nM | 8.17 |
| CHEMBL4075225 | — | IC50 | = | 7.062 | nM | 8.15 |
| CHEMBL4105585 | — | IC50 | = | 7.298 | nM | 8.14 |
| CHEMBL4095083 | — | IC50 | = | 17.52 | nM | 7.76 |
| CHEMBL484701 | — | IC50 | = | 18.76 | nM | 7.73 |
| CHEMBL4091983 | — | IC50 | = | 28.87 | nM | 7.54 |
| CHEMBL4077282 | — | IC50 | = | 30.01 | nM | 7.52 |
| CHEMBL4075298 | — | IC50 | = | 198.2 | nM | 6.70 |
| CHEMBL4065491 | — | IC50 | = | 738.2 | nM | 6.13 |