Assay Detail
Functional
CHEMBL4042175
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Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Urea-containing peptide boronic acids as potent proteasome inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.84 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.12 |
| CHEMBL4089402 | — | — | 1 | 8.11 |
| CHEMBL4095083 | — | — | 1 | 7.57 |
| CHEMBL4100727 | — | — | 1 | 7.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL4089402 | — | IC50 | = | 7.71 | nM | 8.11 |
| CHEMBL4095083 | — | IC50 | = | 26.96 | nM | 7.57 |
| CHEMBL4100727 | — | IC50 | = | 28.53 | nM | 7.54 |