Assay Detail
Binding
CHEMBL4042611
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Agonist activity at human GPR35 expressed in CHO-K1 cells by DMR assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 2H-Chromen-2-one Derivatives as G Protein-Coupled Receptor-35 Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.57 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL177880 | PAMOIC ACID | — | 1 | 8.70 |
| CHEMBL1914576 | — | — | 1 | 7.50 |
| CHEMBL428880 | CROMOLYN | 4.0 | 1 | 7.28 |
| CHEMBL28079 | ZAPRINAST | 2.0 | 1 | 6.80 |
| CHEMBL299155 | TRANSTORINE | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL177880 | PAMOIC ACID | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1914576 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL428880 | CROMOLYN | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL28079 | ZAPRINAST | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL299155 | TRANSTORINE | EC50 | = | 152000.0 | nM | - |