Assay Detail
Functional
CHEMBL4042867
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Growth inhibition of human HCT15 cells after 24 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-15 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Solvent free, catalyst free, microwave or grinding assisted synthesis of bis-cyclic imide derivatives and their evaluation for anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.50 | 4.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4060286 | — | — | 1 | 4.84 |
| CHEMBL4070620 | — | — | 1 | 4.75 |
| CHEMBL4079481 | — | — | 1 | 4.68 |
| CHEMBL4097759 | — | — | 1 | 4.64 |
| CHEMBL4083886 | — | — | 1 | 4.62 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.35 |
| CHEMBL123292 | CYCLOHEXIMIDE | 2.0 | 1 | 4.28 |
| CHEMBL4103728 | — | — | 1 | 4.20 |
| CHEMBL88 | CYCLOPHOSPHAMIDE ANHYDROUS | 4.0 | 1 | 4.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4060286 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL4070620 | — | IC50 | = | 17900.0 | nM | 4.75 |
| CHEMBL4079481 | — | IC50 | = | 21100.0 | nM | 4.68 |
| CHEMBL4097759 | — | IC50 | = | 22700.0 | nM | 4.64 |
| CHEMBL4083886 | — | IC50 | = | 23800.0 | nM | 4.62 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 45010.0 | nM | 4.35 |
| CHEMBL123292 | CYCLOHEXIMIDE | IC50 | = | 52300.0 | nM | 4.28 |
| CHEMBL4103728 | — | IC50 | = | 63300.0 | nM | 4.20 |
| CHEMBL88 | CYCLOPHOSPHAMIDE ANHYDROUS | IC50 | = | 76320.0 | nM | 4.12 |