Assay Detail
Binding
CHEMBL4043436
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of His-tagged BRD4 bromodomain 1 (K57 to E168 residues) (unknown origin) after 1 hr by TR-FRET assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Drug Discovery Targeting Bromodomain-Containing Protein 4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.41 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4078267 | — | — | 1 | 9.05 |
| CHEMBL4096313 | — | — | 1 | 8.96 |
| CHEMBL4088597 | — | — | 1 | 8.89 |
| CHEMBL4104956 | — | — | 1 | 8.80 |
| CHEMBL4075943 | — | — | 1 | 8.34 |
| CHEMBL4067346 | — | — | 1 | 7.96 |
| CHEMBL4063051 | — | — | 1 | 7.82 |
| CHEMBL4075159 | — | — | 1 | 7.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4078267 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL4096313 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL4088597 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL4104956 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL4075943 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL4067346 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL4063051 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL4075159 | — | Ki | = | 38.0 | nM | 7.42 |