Assay Detail
Binding
CHEMBL4043555
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CA1 by stopped-flow CO2 hydrase assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Bortezomib inhibits mammalian carbonic anhydrases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.91 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.60 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 5.89 |
| CHEMBL378506 | BENZOXABOROLE | — | 1 | 5.25 |
| CHEMBL21485 | PHENYLBORONIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL325041 | BORTEZOMIB | Ki | = | 1290.0 | nM | 5.89 |
| CHEMBL378506 | BENZOXABOROLE | Ki | = | 5690.0 | nM | 5.25 |
| CHEMBL21485 | PHENYLBORONIC ACID | Ki | > | 50000.0 | nM | - |