Assay Detail
Functional
CHEMBL4043712
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 LAI infected in human MT2 cells assessed as reduction in p24 Gag protein production incubated for 6 days by automated chemiluminescent enzyme immunoassay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.03 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1323 | DARUNAVIR | 4.0 | 1 | 8.49 |
| CHEMBL4069842 | — | — | 1 | 7.64 |
| CHEMBL3627879 | — | — | 1 | 7.51 |
| CHEMBL4091454 | — | — | 1 | 7.50 |
| CHEMBL3683774 | — | — | 1 | 7.50 |
| CHEMBL4099188 | — | — | 1 | 7.48 |
| CHEMBL3683778 | — | — | 1 | 7.16 |
| CHEMBL4072694 | — | — | 1 | 6.96 |
| CHEMBL4060650 | — | — | 1 | 6.79 |
| CHEMBL4088865 | — | — | 1 | 6.72 |
| CHEMBL4070536 | — | — | 1 | 6.66 |
| CHEMBL4096744 | — | — | 1 | 6.55 |
| CHEMBL4092187 | — | — | 1 | 6.54 |
| CHEMBL4081160 | — | — | 1 | 6.49 |
| CHEMBL3683757 | — | — | 1 | 6.24 |
| CHEMBL3683771 | — | — | 1 | 6.22 |
| CHEMBL3683772 | — | — | 1 | - |
| CHEMBL3683775 | — | — | 1 | - |
| CHEMBL3683777 | — | — | 1 | - |
| CHEMBL4089041 | — | — | 1 | - |
| CHEMBL4060839 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1323 | DARUNAVIR | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4069842 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3627879 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4091454 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3683774 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4099188 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3683778 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4072694 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL4060650 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL4088865 | — | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL4070536 | — | IC50 | = | 221.0 | nM | 6.66 |
| CHEMBL4096744 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4092187 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4081160 | — | IC50 | = | 327.0 | nM | 6.49 |
| CHEMBL3683757 | — | IC50 | = | 581.0 | nM | 6.24 |
| CHEMBL3683771 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3683772 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3683775 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3683777 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4089041 | — | IC50 | - | — | - | |
| CHEMBL4060839 | — | IC50 | - | — | - |