Assay Detail
Binding
CHEMBL4044308
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Inhibition of bovine milk xanthine oxidase pre-incubated for 30 mins followed by xanthine addition and measured every 30 secs for 5 mins by spectrophotometry
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of hydroxychalcones as multifunctional non-purine xanthine oxidase inhibitors for the treatment of hyperuricemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.21 | 4.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1467 | ALLOPURINOL | 4.0 | 1 | 4.71 |
| CHEMBL129795 | ISOLIQUIRITIGENIN | — | 1 | 4.33 |
| CHEMBL148472 | — | — | 1 | 4.25 |
| CHEMBL32147 | 2'-HYDROXYCHALCONE | — | 1 | 4.15 |
| CHEMBL126804 | — | — | 1 | 4.10 |
| CHEMBL150755 | — | — | 1 | 4.06 |
| CHEMBL4088114 | — | — | 1 | 4.05 |
| CHEMBL3823220 | — | — | 1 | 4.04 |
| CHEMBL2282149 | — | — | 1 | - |
| CHEMBL147067 | — | — | 1 | - |
| CHEMBL388322 | 3-HYDROXY CHALCONE | — | 1 | - |
| CHEMBL7747 | 4-HYDROXYCHALCONE | — | 1 | - |
| CHEMBL105310 | 2',4'-DIHYDROXYCHALCONE | — | 1 | - |
| CHEMBL4066829 | — | — | 1 | - |
| CHEMBL1083821 | — | — | 1 | - |
| CHEMBL165 | RESVERATROL | 3.0 | 1 | - |
| CHEMBL145927 | 4,4'-DIHYDROXYCHALCONE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1467 | ALLOPURINOL | IC50 | = | 19600.0 | nM | 4.71 |
| CHEMBL129795 | ISOLIQUIRITIGENIN | IC50 | = | 47300.0 | nM | 4.33 |
| CHEMBL148472 | — | IC50 | = | 56800.0 | nM | 4.25 |
| CHEMBL32147 | 2'-HYDROXYCHALCONE | IC50 | = | 71300.0 | nM | 4.15 |
| CHEMBL126804 | — | IC50 | = | 79400.0 | nM | 4.10 |
| CHEMBL150755 | — | IC50 | = | 87400.0 | nM | 4.06 |
| CHEMBL4088114 | — | IC50 | = | 88300.0 | nM | 4.05 |
| CHEMBL3823220 | — | IC50 | = | 91800.0 | nM | 4.04 |
| CHEMBL2282149 | — | IC50 | = | 165000.0 | nM | - |
| CHEMBL147067 | — | IC50 | = | 145000.0 | nM | - |
| CHEMBL388322 | 3-HYDROXY CHALCONE | IC50 | = | 228000.0 | nM | - |
| CHEMBL7747 | 4-HYDROXYCHALCONE | IC50 | = | 159000.0 | nM | - |
| CHEMBL105310 | 2',4'-DIHYDROXYCHALCONE | IC50 | = | 107000.0 | nM | - |
| CHEMBL4066829 | — | IC50 | = | 133000.0 | nM | - |
| CHEMBL1083821 | — | IC50 | = | 108000.0 | nM | - |
| CHEMBL165 | RESVERATROL | IC50 | - | — | - | |
| CHEMBL145927 | 4,4'-DIHYDROXYCHALCONE | IC50 | = | 117000.0 | nM | - |