Assay Detail

CHEMBL4044535

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Functional

Antiproliferative activity against human HL60 cells after 48 hrs

ChEMBL ↗

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Target

HL-60 (CHEMBL383) ↗

Open DB target context

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HL-60 (CHEMBL383) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target HL-60

CHEMBL383

Anchored from Assay target.

Protein identity HL-60

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	HL-60
Confidence	1 — Organism
Curated By	Autocuration

Target

HL-60 (CHEMBL383) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Recent synthetic and medicinal perspectives of tryptanthrin.

Kaur R, Manjal SK, Rawal RK, Kumar K.
Bioorg Med Chem (2017) 25 : 4533 -4552
PubMed 28720329 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	5.70	5.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL306946	TRYPTANTHRIN	—	1	5.70

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL306946	TRYPTANTHRIN	IC50	=	2000.0	nM	5.70