Assay Detail
Binding
CHEMBL4044730
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Inhibition of recombinant human HSL expressed in baculovirus infected sf9 insect cells using PNPB as substrate after 5 mins by spectrophotometric analysis
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and pharmacological evaluation of a novel series of hormone sensitive lipase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.86 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4063082 | — | — | 1 | 8.70 |
| CHEMBL4063918 | — | — | 1 | 8.10 |
| CHEMBL4085494 | — | — | 1 | 7.72 |
| CHEMBL4075264 | — | — | 1 | 7.17 |
| CHEMBL4062547 | — | — | 1 | 7.04 |
| CHEMBL4102589 | — | — | 1 | 7.00 |
| CHEMBL4059792 | — | — | 1 | 6.96 |
| CHEMBL4100977 | — | — | 1 | 6.64 |
| CHEMBL4082999 | — | — | 1 | 6.55 |
| CHEMBL4078327 | — | — | 1 | 6.24 |
| CHEMBL4081717 | — | — | 1 | 6.09 |
| CHEMBL4072513 | — | — | 1 | 6.09 |
| CHEMBL4064703 | — | — | 1 | 6.07 |
| CHEMBL4101916 | — | — | 1 | 5.72 |
| CHEMBL4093246 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4063082 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4063918 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4085494 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4075264 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL4062547 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL4102589 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4059792 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4100977 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4082999 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4078327 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL4081717 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL4072513 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL4064703 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL4101916 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4093246 | — | IC50 | > | 5000.0 | nM | - |