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Assay Detail

CHEMBL4044822

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against wild type Herpes simplex virus 1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathic effect
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human alphaherpesvirus 1
Confidence 1 — Organism
Curated By Autocuration

Target

Human alphaherpesvirus 1 (CHEMBL377)
Type ORGANISM
Organism Human alphaherpesvirus 1

Publication

New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
Krečmerová M, Dračínský M, Snoeck R, Balzarini J, Pomeisl K, Andrei G.
Bioorg Med Chem (2017) 25 : 4637 -4648
PubMed 28757102 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 20 5.67 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL31634 BRIVUDINE 2.0 1 7.40
CHEMBL182 GANCICLOVIR 4.0 1 7.40
CHEMBL4093465 1 6.46
CHEMBL184 ACYCLOVIR 4.0 1 6.40
CHEMBL4072751 1 6.22
CHEMBL4071676 1 6.08
CHEMBL4101168 1 5.58
CHEMBL5314375 CIDOFOVIR 4.0 1 5.53
CHEMBL1823516 1 5.41
CHEMBL4103271 1 5.00
CHEMBL4063056 1 4.66
CHEMBL4082206 1 4.49
CHEMBL4074426 1 4.40
CHEMBL298845 1 4.35
CHEMBL4062012 1 -
CHEMBL4090051 1 -
CHEMBL4085723 1 -
CHEMBL4064156 1 -
CHEMBL4100217 1 -
CHEMBL4092474 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL31634 BRIVUDINE EC50 = 40.0 nM 7.40
CHEMBL182 GANCICLOVIR EC50 = 40.0 nM 7.40
CHEMBL4093465 EC50 = 350.0 nM 6.46
CHEMBL184 ACYCLOVIR EC50 = 400.0 nM 6.40
CHEMBL4072751 EC50 = 600.0 nM 6.22
CHEMBL4071676 EC50 = 840.0 nM 6.08
CHEMBL4101168 EC50 = 2620.0 nM 5.58
CHEMBL5314375 CIDOFOVIR EC50 = 2930.0 nM 5.53
CHEMBL1823516 EC50 = 3900.0 nM 5.41
CHEMBL4103271 EC50 = 10000.0 nM 5.00
CHEMBL4063056 EC50 = 22000.0 nM 4.66
CHEMBL4082206 EC50 = 32500.0 nM 4.49
CHEMBL4074426 EC50 = 39500.0 nM 4.40
CHEMBL298845 EC50 = 45000.0 nM 4.35
CHEMBL4062012 EC50 > 100000.0 nM -
CHEMBL4090051 EC50 > 100000.0 nM -
CHEMBL4085723 EC50 > 100000.0 nM -
CHEMBL4064156 EC50 > 100000.0 nM -
CHEMBL4100217 EC50 = 142000.0 nM -
CHEMBL4092474 EC50 > 100000.0 nM -