Assay Detail
Functional
CHEMBL4045105
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assay
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological investigation of tetrahydropyridopyrimidinone derivatives as potential multireceptor atypical antipsychotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 37 | 7.13 | 8.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4083333 | — | — | 1 | 8.34 |
| CHEMBL4087132 | — | — | 1 | 8.15 |
| CHEMBL4104261 | — | — | 1 | 8.14 |
| CHEMBL4102670 | — | — | 1 | 8.01 |
| CHEMBL4074326 | — | — | 1 | 7.99 |
| CHEMBL4102561 | — | — | 1 | 7.99 |
| CHEMBL4094825 | — | — | 1 | 7.98 |
| CHEMBL4077006 | — | — | 1 | 7.77 |
| CHEMBL4079251 | — | — | 1 | 7.62 |
| CHEMBL4100152 | — | — | 1 | 7.58 |
| CHEMBL4087246 | — | — | 1 | 7.54 |
| CHEMBL4067506 | — | — | 1 | 7.51 |
| CHEMBL4103509 | — | — | 1 | 7.48 |
| CHEMBL4094926 | — | — | 1 | 7.47 |
| CHEMBL4105102 | — | — | 1 | 7.16 |
| CHEMBL4078409 | — | — | 1 | 7.12 |
| CHEMBL4061068 | — | — | 1 | 6.52 |
| CHEMBL4097395 | — | — | 1 | 6.35 |
| CHEMBL4101115 | — | — | 1 | 6.31 |
| CHEMBL4079365 | — | — | 1 | 6.22 |
| CHEMBL4074373 | — | — | 1 | 6.17 |
| CHEMBL4084663 | — | — | 1 | 6.11 |
| CHEMBL4091554 | — | — | 1 | 6.05 |
| CHEMBL4082150 | — | — | 1 | 5.96 |
| CHEMBL4062992 | — | — | 1 | 5.89 |
| CHEMBL4060678 | — | — | 1 | 5.86 |
| CHEMBL4082084 | — | — | 1 | - |
| CHEMBL4096467 | — | — | 1 | - |
| CHEMBL4077702 | — | — | 1 | - |
| CHEMBL4090872 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4083333 | — | EC50 | = | 4.57 | nM | 8.34 |
| CHEMBL4087132 | — | EC50 | = | 7.09 | nM | 8.15 |
| CHEMBL4104261 | — | EC50 | = | 7.2 | nM | 8.14 |
| CHEMBL4102670 | — | EC50 | = | 9.75 | nM | 8.01 |
| CHEMBL4074326 | — | EC50 | = | 10.2 | nM | 7.99 |
| CHEMBL4102561 | — | EC50 | = | 10.2 | nM | 7.99 |
| CHEMBL4094825 | — | EC50 | = | 10.5 | nM | 7.98 |
| CHEMBL4077006 | — | EC50 | = | 16.9 | nM | 7.77 |
| CHEMBL4079251 | — | EC50 | = | 24.22 | nM | 7.62 |
| CHEMBL4100152 | — | EC50 | = | 26.2 | nM | 7.58 |
| CHEMBL4087246 | — | EC50 | = | 28.6 | nM | 7.54 |
| CHEMBL4067506 | — | EC50 | = | 30.8 | nM | 7.51 |
| CHEMBL4103509 | — | EC50 | = | 32.9 | nM | 7.48 |
| CHEMBL4094926 | — | EC50 | = | 34.1 | nM | 7.47 |
| CHEMBL4105102 | — | EC50 | = | 69.7 | nM | 7.16 |
| CHEMBL4078409 | — | EC50 | = | 76.2 | nM | 7.12 |
| CHEMBL4061068 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4097395 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4101115 | — | EC50 | = | 488.0 | nM | 6.31 |
| CHEMBL4079365 | — | EC50 | = | 607.0 | nM | 6.22 |
| CHEMBL4074373 | — | EC50 | = | 680.0 | nM | 6.17 |
| CHEMBL4084663 | — | EC50 | = | 770.0 | nM | 6.11 |
| CHEMBL4091554 | — | EC50 | = | 899.0 | nM | 6.05 |
| CHEMBL4082150 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4062992 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4060678 | — | EC50 | = | 1395.0 | nM | 5.86 |
| CHEMBL4064609 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4063748 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4065710 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4098594 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1621 | PALIPERIDONE | EC50 | > | 10000.0 | nM | - |
| CHEMBL85 | RISPERIDONE | EC50 | > | 10000.0 | nM | - |
| CHEMBL4062936 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4090872 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4077702 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4096467 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4082084 | — | EC50 | > | 10000.0 | nM | - |