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Assay Detail

CHEMBL4045494

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against rat L6 cells assessed as cell viability after 72 hrs by Alamar blue assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Rattus norvegicus
Cell Type L6
Confidence 1 — Organism
Curated By Autocuration

Target

L6 (CHEMBL614793)
Type CELL-LINE
Organism Rattus norvegicus

Publication

Lead selection of antiparasitic compounds from a focused library of benzenesulfonyl derivatives of heterocycles.
Pagliero RJ, Kaiser M, Brun R, Nieto MJ, Mazzieri MR.
Bioorg Med Chem Lett (2017) 27 : 3945 -3949
PubMed 28789893 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.24 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL61 PODOFILOX 4.0 1 8.00
CHEMBL4067459 1 6.36
CHEMBL4104679 1 5.57
CHEMBL4070401 1 5.44
CHEMBL4060175 1 5.18
CHEMBL4075894 1 5.17
CHEMBL4070437 1 5.05
CHEMBL4072453 1 5.04
CHEMBL4105065 1 4.96
CHEMBL4094002 1 4.92
CHEMBL4077238 1 4.91
CHEMBL4063225 1 4.91
CHEMBL4068026 1 4.90
CHEMBL4094889 1 4.88
CHEMBL4072095 1 4.88
CHEMBL4086745 1 4.82
CHEMBL4102778 1 4.16

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL61 PODOFILOX IC50 = 10.0 nM 8.00
CHEMBL4067459 IC50 = 440.0 nM 6.36
CHEMBL4104679 IC50 = 2710.0 nM 5.57
CHEMBL4070401 IC50 = 3600.0 nM 5.44
CHEMBL4060175 IC50 = 6620.0 nM 5.18
CHEMBL4075894 IC50 = 6810.0 nM 5.17
CHEMBL4070437 IC50 = 8970.0 nM 5.05
CHEMBL4072453 IC50 = 9100.0 nM 5.04
CHEMBL4105065 IC50 = 11100.0 nM 4.96
CHEMBL4094002 IC50 = 12160.0 nM 4.92
CHEMBL4077238 IC50 = 12250.0 nM 4.91
CHEMBL4063225 IC50 = 12380.0 nM 4.91
CHEMBL4068026 IC50 = 12550.0 nM 4.90
CHEMBL4094889 IC50 = 13200.0 nM 4.88
CHEMBL4072095 IC50 = 13100.0 nM 4.88
CHEMBL4086745 IC50 = 15100.0 nM 4.82
CHEMBL4102778 IC50 = 69400.0 nM 4.16