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Assay Detail

CHEMBL4045540

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of P2Y12 in human platelet rich plasma assessed as reduction in ADP-induced platelet aggregation pre-incubated before ADP addition and measured after 10 mins by Bruker spectrophotometry
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

P2Y purinoceptor 12 (CHEMBL2001)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Facile alkylation of 4-nitrobenzotriazole and its platelet aggregation inhibitory activity.
Singh D, Silakari O.
Bioorg Med Chem (2017) 25 : 5260 -5267
PubMed 28789912 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 6.50 6.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL398435 TICAGRELOR 4.0 1 6.50
CHEMBL4093411 1 -
CHEMBL84963 BENZOTRIAZOLE 1 -
CHEMBL1456115 1 -
CHEMBL4073608 1 -
CHEMBL4099652 1 -
CHEMBL4084826 1 -
CHEMBL4102781 1 -
CHEMBL4076556 1 -
CHEMBL4100042 1 -
CHEMBL4062156 1 -
CHEMBL4075142 1 -
CHEMBL4078992 1 -
CHEMBL4076196 1 -
CHEMBL4087845 1 -
CHEMBL4075331 1 -
CHEMBL4075411 1 -
CHEMBL4067755 1 -
CHEMBL4077654 1 -
CHEMBL4079813 1 -
CHEMBL4060620 1 -
CHEMBL4075841 1 -
CHEMBL4065540 1 -
CHEMBL4077194 1 -
CHEMBL4087693 1 -
CHEMBL4071889 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL398435 TICAGRELOR IC50 = 320.0 nM 6.50
CHEMBL4093411 IC50 = 1040000.0 nM -
CHEMBL84963 BENZOTRIAZOLE IC50 = 7430000.0 nM -
CHEMBL1456115 IC50 = 2060000.0 nM -
CHEMBL4073608 IC50 = 1840000.0 nM -
CHEMBL4099652 IC50 = 1960000.0 nM -
CHEMBL4084826 IC50 = 1800000.0 nM -
CHEMBL4102781 IC50 = 1500000.0 nM -
CHEMBL4076556 IC50 = 1620000.0 nM -
CHEMBL4100042 IC50 = 1300000.0 nM -
CHEMBL4062156 IC50 = 1320000.0 nM -
CHEMBL4075142 IC50 = 1050000.0 nM -
CHEMBL4078992 IC50 = 1070000.0 nM -
CHEMBL4076196 IC50 = 1070000.0 nM -
CHEMBL4087845 IC50 = 940000.0 nM -
CHEMBL4075331 IC50 = 950000.0 nM -
CHEMBL4075411 IC50 = 930000.0 nM -
CHEMBL4067755 IC50 = 940000.0 nM -
CHEMBL4077654 IC50 = 920000.0 nM -
CHEMBL4079813 IC50 = 910000.0 nM -
CHEMBL4060620 IC50 = 1260000.0 nM -
CHEMBL4075841 IC50 = 810000.0 nM -
CHEMBL4065540 IC50 = 820000.0 nM -
CHEMBL4077194 IC50 = 650000.0 nM -
CHEMBL4087693 IC50 = 860000.0 nM -
CHEMBL4071889 IC50 = 1020000.0 nM -