Assay Detail
Functional
CHEMBL4045567
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel antitumor spirotetrahydrothiopyran-oxindole derivatives as potent p53-MDM2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.05 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4103052 | — | — | 1 | 5.62 |
| CHEMBL4085100 | — | — | 1 | 5.37 |
| CHEMBL4087333 | — | — | 1 | 5.29 |
| CHEMBL4100837 | — | — | 1 | 5.25 |
| CHEMBL4089755 | — | — | 1 | 5.10 |
| CHEMBL4067591 | — | — | 1 | 5.08 |
| CHEMBL4076023 | — | — | 1 | 5.07 |
| CHEMBL4105189 | — | — | 1 | 5.07 |
| CHEMBL4068639 | — | — | 1 | 5.07 |
| CHEMBL4082861 | — | — | 1 | 5.06 |
| CHEMBL4098502 | — | — | 1 | 5.03 |
| CHEMBL4080485 | — | — | 1 | 5.02 |
| CHEMBL4095014 | — | — | 1 | 5.01 |
| CHEMBL4079450 | — | — | 1 | 4.98 |
| CHEMBL4097488 | — | — | 1 | 4.98 |
| CHEMBL4071267 | — | — | 1 | 4.98 |
| CHEMBL4095297 | — | — | 1 | 4.76 |
| CHEMBL4074857 | — | — | 1 | 4.72 |
| CHEMBL2152332 | — | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4103052 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4085100 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4087333 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4100837 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4089755 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4067591 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL4076023 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL4105189 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL4068639 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL4082861 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL4098502 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL4080485 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL4095014 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL4079450 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL4097488 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL4071267 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL4095297 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL4074857 | — | IC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL2152332 | — | IC50 | = | 28400.0 | nM | 4.55 |