Assay Detail
Binding
CHEMBL4045568
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PMDM6-F peptide binding to MDM2 binding domain (1 to 118 residues) (unknown origin) by fluorescence polarization binding assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel antitumor spirotetrahydrothiopyran-oxindole derivatives as potent p53-MDM2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 19 | 5.44 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2152332 | — | — | 1 | 6.82 |
| CHEMBL4085100 | — | — | 1 | 5.71 |
| CHEMBL4082861 | — | — | 1 | 5.52 |
| CHEMBL4100837 | — | — | 1 | 5.52 |
| CHEMBL4076023 | — | — | 1 | 5.47 |
| CHEMBL4079450 | — | — | 1 | 5.47 |
| CHEMBL4097488 | — | — | 1 | 5.47 |
| CHEMBL4105189 | — | — | 1 | 5.40 |
| CHEMBL4098502 | — | — | 1 | 5.39 |
| CHEMBL4068639 | — | — | 1 | 5.39 |
| CHEMBL4089755 | — | — | 1 | 5.38 |
| CHEMBL4103052 | — | — | 1 | 5.38 |
| CHEMBL4080485 | — | — | 1 | 5.33 |
| CHEMBL4095014 | — | — | 1 | 5.32 |
| CHEMBL4095297 | — | — | 1 | 5.31 |
| CHEMBL4087333 | — | — | 1 | 5.28 |
| CHEMBL4067591 | — | — | 1 | 5.19 |
| CHEMBL4074857 | — | — | 1 | 5.00 |
| CHEMBL4071267 | — | — | 1 | 4.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2152332 | — | Kd | = | 150.0 | nM | 6.82 |
| CHEMBL4085100 | — | Kd | = | 1970.0 | nM | 5.71 |
| CHEMBL4082861 | — | Kd | = | 3000.0 | nM | 5.52 |
| CHEMBL4100837 | — | Kd | = | 3000.0 | nM | 5.52 |
| CHEMBL4076023 | — | Kd | = | 3400.0 | nM | 5.47 |
| CHEMBL4079450 | — | Kd | = | 3400.0 | nM | 5.47 |
| CHEMBL4097488 | — | Kd | = | 3400.0 | nM | 5.47 |
| CHEMBL4105189 | — | Kd | = | 4000.0 | nM | 5.40 |
| CHEMBL4098502 | — | Kd | = | 4100.0 | nM | 5.39 |
| CHEMBL4068639 | — | Kd | = | 4100.0 | nM | 5.39 |
| CHEMBL4089755 | — | Kd | = | 4200.0 | nM | 5.38 |
| CHEMBL4103052 | — | Kd | = | 4200.0 | nM | 5.38 |
| CHEMBL4080485 | — | Kd | = | 4700.0 | nM | 5.33 |
| CHEMBL4095014 | — | Kd | = | 4800.0 | nM | 5.32 |
| CHEMBL4095297 | — | Kd | = | 4900.0 | nM | 5.31 |
| CHEMBL4087333 | — | Kd | = | 5200.0 | nM | 5.28 |
| CHEMBL4067591 | — | Kd | = | 6400.0 | nM | 5.19 |
| CHEMBL4074857 | — | Kd | = | 10100.0 | nM | 5.00 |
| CHEMBL4071267 | — | Kd | = | 11700.0 | nM | 4.93 |