Assay Detail
Functional
CHEMBL4045586
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of pyrazolopyrimidine arylsulfonamides as CC-chemokine receptor 4 (CCR4) antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.22 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2018954 | — | — | 1 | 8.41 |
| CHEMBL2018953 | — | — | 1 | 8.26 |
| CHEMBL4060413 | — | — | 1 | 7.20 |
| CHEMBL4071299 | — | — | 1 | 7.10 |
| CHEMBL4069639 | — | — | 1 | 7.10 |
| CHEMBL4069103 | — | — | 1 | 6.80 |
| CHEMBL4088207 | — | — | 1 | 6.70 |
| CHEMBL4080352 | — | — | 1 | 6.60 |
| CHEMBL4096860 | — | — | 1 | 6.60 |
| CHEMBL4098813 | — | — | 1 | 6.60 |
| CHEMBL4068045 | — | — | 1 | 6.50 |
| CHEMBL4089151 | — | — | 1 | 6.50 |
| CHEMBL4071815 | — | — | 1 | 6.30 |
| CHEMBL3310825 | — | — | 1 | 6.22 |
| CHEMBL4093509 | — | — | 1 | 6.20 |
| CHEMBL4095437 | — | — | 1 | 6.20 |
| CHEMBL4066934 | — | — | 1 | 6.20 |
| CHEMBL4091069 | — | — | 1 | 6.10 |
| CHEMBL4060967 | — | — | 1 | 6.10 |
| CHEMBL4082318 | — | — | 1 | 6.10 |
| CHEMBL4067451 | — | — | 1 | 6.10 |
| CHEMBL4093994 | — | — | 1 | 5.90 |
| CHEMBL4097341 | — | — | 1 | 5.70 |
| CHEMBL4078359 | — | — | 1 | 5.50 |
| CHEMBL4065904 | — | — | 1 | 5.50 |
| CHEMBL4104585 | — | — | 1 | 5.40 |
| CHEMBL4059913 | — | — | 1 | 5.10 |
| CHEMBL4088688 | — | — | 1 | 5.00 |
| CHEMBL4098333 | — | — | 1 | 5.00 |
| CHEMBL4066451 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2018954 | — | IC50 | = | 3.89 | nM | 8.41 |
| CHEMBL2018953 | — | IC50 | = | 5.495 | nM | 8.26 |
| CHEMBL4060413 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL4071299 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL4069639 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL4069103 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL4088207 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL4080352 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL4096860 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL4098813 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL4068045 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL4089151 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL4071815 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL3310825 | — | IC50 | = | 602.56 | nM | 6.22 |
| CHEMBL4095437 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL4066934 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL4093509 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL4091069 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL4060967 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL4082318 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL4067451 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL4093994 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL4097341 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL4065904 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL4078359 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL4104585 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL4059913 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL4088688 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4098333 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4066451 | — | IC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL4090166 | — | IC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL4063189 | — | IC50 | > | 31622.78 | nM | - |
| CHEMBL4081830 | — | IC50 | > | 31622.78 | nM | - |