Assay Detail
Binding
CHEMBL4046589
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TYK2 (unknown origin) by biochemical assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Non-receptor tyrosine-protein kinase TYK2 (CHEMBL3553) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 32 | 8.61 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4084436 | — | — | 1 | 9.52 |
| CHEMBL4062758 | — | — | 1 | 9.40 |
| CHEMBL4075453 | — | — | 1 | 9.30 |
| CHEMBL4071399 | — | — | 1 | 9.30 |
| CHEMBL3675685 | — | — | 1 | 9.30 |
| CHEMBL4062680 | — | — | 1 | 9.22 |
| CHEMBL4092116 | — | — | 1 | 9.22 |
| CHEMBL4093872 | — | — | 1 | 9.22 |
| CHEMBL4069942 | — | — | 1 | 9.22 |
| CHEMBL4074130 | — | — | 1 | 9.22 |
| CHEMBL4076947 | — | — | 1 | 9.15 |
| CHEMBL4092191 | — | — | 1 | 9.15 |
| CHEMBL4099854 | — | — | 1 | 9.15 |
| CHEMBL4093172 | — | — | 1 | 9.10 |
| CHEMBL4070262 | — | — | 1 | 9.00 |
| CHEMBL4080904 | — | — | 1 | 8.92 |
| CHEMBL4097446 | — | — | 1 | 8.92 |
| CHEMBL4100889 | — | — | 1 | 8.89 |
| CHEMBL2387223 | — | — | 1 | 8.80 |
| CHEMBL4064189 | — | — | 1 | 8.77 |
| CHEMBL4065419 | — | — | 1 | 8.49 |
| CHEMBL2387224 | — | — | 1 | 8.32 |
| CHEMBL4105148 | — | — | 1 | 8.29 |
| CHEMBL4068427 | — | — | 1 | 8.06 |
| CHEMBL4093092 | — | — | 1 | 8.00 |
| CHEMBL4075131 | — | — | 1 | 7.89 |
| CHEMBL4101734 | — | — | 1 | 7.77 |
| CHEMBL4089568 | — | — | 1 | 7.72 |
| CHEMBL4085414 | — | — | 1 | 7.70 |
| CHEMBL4103341 | — | — | 1 | 7.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4084436 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL4062758 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL4075453 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL4071399 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL3675685 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL4062680 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL4092116 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL4093872 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL4069942 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL4074130 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL4076947 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL4092191 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL4099854 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL4093172 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL4070262 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL4097446 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL4080904 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL4100889 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL2387223 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL4064189 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL4065419 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL2387224 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL4105148 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL4068427 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL4093092 | — | Ki | = | 9.9 | nM | 8.00 |
| CHEMBL4075131 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL4101734 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL4089568 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL4085414 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL4103341 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL4082575 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL4086518 | — | Ki | = | 3500.0 | nM | 5.46 |