Assay Detail
Binding
CHEMBL4046592
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TYK2 (unknown origin) assessed as reduction in IL-23 induced STAT3 phosphorylation by cell based ELISA
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Non-receptor tyrosine-protein kinase TYK2 (CHEMBL3553) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 6.60 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4092191 | — | — | 1 | 7.46 |
| CHEMBL4071399 | — | — | 1 | 7.36 |
| CHEMBL4097446 | — | — | 1 | 7.23 |
| CHEMBL4076947 | — | — | 1 | 7.18 |
| CHEMBL4062680 | — | — | 1 | 7.14 |
| CHEMBL4080904 | — | — | 1 | 6.85 |
| CHEMBL4069942 | — | — | 1 | 6.85 |
| CHEMBL4062758 | — | — | 1 | 6.77 |
| CHEMBL4093872 | — | — | 1 | 6.70 |
| CHEMBL4084436 | — | — | 1 | 6.58 |
| CHEMBL4070262 | — | — | 1 | 6.44 |
| CHEMBL4092116 | — | — | 1 | 6.35 |
| CHEMBL4075453 | — | — | 1 | 6.28 |
| CHEMBL2387223 | — | — | 1 | 5.92 |
| CHEMBL4099854 | — | — | 1 | 5.44 |
| CHEMBL4105148 | — | — | 1 | 5.03 |
| CHEMBL4065419 | — | — | 1 | - |
| CHEMBL4093092 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4092191 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4071399 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4097446 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4076947 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL4062680 | — | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4080904 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4069942 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4062758 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4093872 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4084436 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4070262 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4092116 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4075453 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL2387223 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4099854 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4105148 | — | EC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL4065419 | — | EC50 | - | — | - | |
| CHEMBL4093092 | — | EC50 | - | — | - |