Assay Detail
Binding
CHEMBL4047023
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Agonist activity at full length ERalpha (unknown origin) expressed in human HeLa cells incubated for 24 hrs by ERE-driven luciferase reporter gene assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of benzoacridines as estrogenic and anti-estrogenic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 5.62 | 5.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4092300 | — | — | 1 | 5.88 |
| CHEMBL4087989 | — | — | 1 | 5.84 |
| CHEMBL4088694 | — | — | 1 | 5.13 |
| CHEMBL4094003 | — | — | 1 | - |
| CHEMBL4066690 | — | — | 1 | - |
| CHEMBL4071506 | — | — | 1 | - |
| CHEMBL4105062 | — | — | 1 | - |
| CHEMBL4071813 | — | — | 1 | - |
| CHEMBL83 | TAMOXIFEN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4092300 | — | EC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL4087989 | — | EC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL4088694 | — | EC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4094003 | — | EC50 | - | — | - | |
| CHEMBL4066690 | — | EC50 | - | — | - | |
| CHEMBL4071506 | — | EC50 | - | — | - | |
| CHEMBL4105062 | — | EC50 | - | — | - | |
| CHEMBL4071813 | — | EC50 | - | — | - | |
| CHEMBL83 | TAMOXIFEN | EC50 | - | — | - |