Assay Detail
Functional
CHEMBL4047136
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Cytotoxicity against human MM1S cells after 48 hrs by MTT assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MM1.S |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship study of small molecule inhibitors of the DEPTOR-mTOR interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.93 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4080997 | — | — | 1 | 6.52 |
| CHEMBL4099027 | — | — | 1 | 6.30 |
| CHEMBL4070357 | — | — | 1 | 6.22 |
| CHEMBL4082200 | — | — | 1 | 6.10 |
| CHEMBL4077014 | — | — | 1 | 6.00 |
| CHEMBL4090045 | — | — | 1 | 5.89 |
| CHEMBL4076172 | — | — | 1 | 5.82 |
| CHEMBL4075851 | — | — | 1 | 5.70 |
| CHEMBL4060289 | — | — | 1 | 5.70 |
| CHEMBL4078352 | — | — | 1 | 5.70 |
| CHEMBL4064715 | — | — | 1 | 5.70 |
| CHEMBL1898589 | — | — | 1 | 5.52 |
| CHEMBL4076263 | — | — | 1 | - |
| CHEMBL4096578 | — | — | 1 | - |
| CHEMBL4069344 | — | — | 1 | - |
| CHEMBL4068967 | — | — | 1 | - |
| CHEMBL4068044 | — | — | 1 | - |
| CHEMBL4090953 | — | — | 1 | - |
| CHEMBL4063047 | — | — | 1 | - |
| CHEMBL4091293 | — | — | 1 | - |
| CHEMBL1881268 | — | — | 1 | - |
| CHEMBL4076332 | — | — | 1 | - |
| CHEMBL4076392 | — | — | 1 | - |
| CHEMBL4098986 | — | — | 1 | - |
| CHEMBL4092413 | — | — | 1 | - |
| CHEMBL4102598 | — | — | 1 | - |
| CHEMBL4084658 | — | — | 1 | - |
| CHEMBL4072829 | — | — | 1 | - |
| CHEMBL4059551 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4080997 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4099027 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4070357 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4082200 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4077014 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4090045 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4076172 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4075851 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4060289 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4078352 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4064715 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1898589 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4076263 | — | IC50 | - | — | - | |
| CHEMBL4096578 | — | IC50 | - | — | - | |
| CHEMBL4069344 | — | IC50 | - | — | - | |
| CHEMBL4068967 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4068044 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4090953 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4063047 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4091293 | — | IC50 | - | — | - | |
| CHEMBL1881268 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4076332 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4076392 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4098986 | — | IC50 | - | — | - | |
| CHEMBL4092413 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4102598 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4084658 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4072829 | — | IC50 | - | — | - | |
| CHEMBL4059551 | — | IC50 | > | 3000.0 | nM | - |