Compound Detail
CHEMBL4084658
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Basic Information
| ChEMBL ID | CHEMBL4084658 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GHRFWGHOYASJJG-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
259.9
MW (Da)
3.30
ALogP
2
HBA
0
HBD
15.6
PSA (Ų)
0.66
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| DEP domain-containing mTOR-interacting protein CHEMBL4105866 | IC50 | 5.89 | 5.89 | 1300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| DEP domain-containing mTOR-interacting protein | IC50 | = | 1300.0 | nM | 5.89 | Inhibition of DEPTOR in human RPMI8226 cells assessed as increase in mTOR kinase... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28916338 | 10.1016/j.bmcl.2017.09.002 | DEP domain-containing mTOR-interacting protein | 3 |
| 28916338 | 10.1016/j.bmcl.2017.09.002 | MM1.S | 1 |
| 28916338 | 10.1016/j.bmcl.2017.09.002 | RPMI-8226 | 1 |
Data from ChEMBL 36 via Core Engine