Assay Detail
Binding
CHEMBL4418216
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of DEPTOR in human RPMI8226 cells assessed as increase in mTOR kinase activity by measuring induction of p70 phosphorylation incubated for 6 hrs by Western blot analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
DEP domain-containing mTOR-interacting protein (CHEMBL4105866) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibitors of mtor-deptor interactions and methods of use thereof
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.08 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4082200 | — | — | 1 | 6.22 |
| CHEMBL4076172 | — | — | 1 | 6.22 |
| CHEMBL4064715 | — | — | 1 | 6.16 |
| CHEMBL4060289 | — | — | 1 | 6.10 |
| CHEMBL4078352 | — | — | 1 | 6.10 |
| CHEMBL4084658 | — | — | 1 | 5.89 |
| CHEMBL1898589 | — | — | 1 | 5.89 |
| CHEMBL4092413 | — | — | 1 | - |
| CHEMBL4102598 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4082200 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4076172 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4064715 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4060289 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4078352 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4084658 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1898589 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4092413 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4102598 | — | IC50 | > | 5000.0 | nM | - |