Assay Detail
Functional
CHEMBL4047805
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-viral activity against HIV-1 LAI infected in human MT2 cells assessed as reduction in p24 Gag protein production
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1'-P2' ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.66 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4067478 | — | — | 1 | 8.70 |
| CHEMBL1323 | DARUNAVIR | 4.0 | 1 | 8.52 |
| CHEMBL4076488 | — | — | 1 | 8.28 |
| CHEMBL4096469 | — | — | 1 | 7.66 |
| CHEMBL4083439 | — | — | 1 | 7.51 |
| CHEMBL4095133 | — | — | 1 | 7.34 |
| CHEMBL4079687 | — | — | 1 | 7.27 |
| CHEMBL4091175 | — | — | 1 | 6.91 |
| CHEMBL4070241 | — | — | 1 | 6.75 |
| CHEMBL4073734 | — | — | 1 | - |
| CHEMBL4096186 | — | — | 1 | - |
| CHEMBL4068907 | — | — | 1 | - |
| CHEMBL4074816 | — | — | 1 | - |
| CHEMBL4095267 | — | — | 1 | - |
| CHEMBL4080889 | — | — | 1 | - |
| CHEMBL4100548 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4067478 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1323 | DARUNAVIR | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4076488 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL4096469 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4083439 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4095133 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4079687 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL4091175 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL4070241 | — | IC50 | = | 176.0 | nM | 6.75 |
| CHEMBL4073734 | — | IC50 | - | — | - | |
| CHEMBL4096186 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4068907 | — | IC50 | - | — | - | |
| CHEMBL4074816 | — | IC50 | - | — | - | |
| CHEMBL4095267 | — | IC50 | - | — | - | |
| CHEMBL4080889 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4100548 | — | IC50 | - | — | - |