Assay Detail
Binding
CHEMBL4048079
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat serum BChE using butyrylthiocholine chloride as substrate incubated for 15 mins by Ellman's method
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 4.77 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4075667 | — | — | 1 | 5.66 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 5.36 |
| CHEMBL4064598 | — | — | 1 | 5.28 |
| CHEMBL3547159 | — | — | 1 | 5.08 |
| CHEMBL4096975 | — | — | 1 | 5.04 |
| CHEMBL4066908 | — | — | 1 | 5.03 |
| CHEMBL4104552 | — | — | 1 | 4.88 |
| CHEMBL4091683 | — | — | 1 | 4.88 |
| CHEMBL4086653 | — | — | 1 | 4.83 |
| CHEMBL4089264 | — | — | 1 | 4.83 |
| CHEMBL4066677 | — | — | 1 | 4.80 |
| CHEMBL4081393 | — | — | 1 | 4.79 |
| CHEMBL4080466 | — | — | 1 | 4.79 |
| CHEMBL4077879 | — | — | 1 | 4.79 |
| CHEMBL4085625 | — | — | 1 | 4.75 |
| CHEMBL4096963 | — | — | 1 | 4.74 |
| CHEMBL4069776 | — | — | 1 | 4.72 |
| CHEMBL3547058 | — | — | 1 | 4.68 |
| CHEMBL4099414 | — | — | 1 | 4.65 |
| CHEMBL4094393 | — | — | 1 | 4.64 |
| CHEMBL4066289 | — | — | 1 | 4.58 |
| CHEMBL4091015 | — | — | 1 | 4.56 |
| CHEMBL4070797 | — | — | 1 | 4.55 |
| CHEMBL4061108 | — | — | 1 | 4.49 |
| CHEMBL4086843 | — | — | 1 | 4.48 |
| CHEMBL4089274 | — | — | 1 | 4.41 |
| CHEMBL4061100 | — | — | 1 | 4.37 |
| CHEMBL4104698 | — | — | 1 | 4.35 |
| CHEMBL4076402 | — | — | 1 | 4.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4075667 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 4420.0 | nM | 5.36 |
| CHEMBL4064598 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL3547159 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL4096975 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL4066908 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL4104552 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL4091683 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL4086653 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL4089264 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL4066677 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL4081393 | — | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL4080466 | — | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL4077879 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL4085625 | — | IC50 | = | 17900.0 | nM | 4.75 |
| CHEMBL4096963 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL4069776 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL3547058 | — | IC50 | = | 20700.0 | nM | 4.68 |
| CHEMBL4099414 | — | IC50 | = | 22500.0 | nM | 4.65 |
| CHEMBL4094393 | — | IC50 | = | 22800.0 | nM | 4.64 |
| CHEMBL4066289 | — | IC50 | = | 26200.0 | nM | 4.58 |
| CHEMBL4091015 | — | IC50 | = | 27700.0 | nM | 4.56 |
| CHEMBL4070797 | — | IC50 | = | 27900.0 | nM | 4.55 |
| CHEMBL4061108 | — | IC50 | = | 32400.0 | nM | 4.49 |
| CHEMBL4086843 | — | IC50 | = | 32900.0 | nM | 4.48 |
| CHEMBL4089274 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL4061100 | — | IC50 | = | 42900.0 | nM | 4.37 |
| CHEMBL4104698 | — | IC50 | = | 44400.0 | nM | 4.35 |
| CHEMBL4076402 | — | IC50 | = | 58500.0 | nM | 4.23 |