Assay Detail
Binding
CHEMBL4048312
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK9/cyclin T1 (unknown origin) using YSPTSPSYSPTSPSYSPTSPKKK as substrate after 30 mins in presence of [33P]-gamma-ATP by filter binding assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery and Preclinical Development of IIIM-290, an Orally Active Potent Cyclin-Dependent Kinase Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.08 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4079206 | — | — | 1 | 8.72 |
| CHEMBL4103469 | — | — | 1 | 7.94 |
| CHEMBL4066369 | — | — | 1 | 7.54 |
| CHEMBL4100359 | — | — | 1 | 7.18 |
| CHEMBL4074270 | — | — | 1 | 6.80 |
| CHEMBL4094775 | — | — | 1 | 6.58 |
| CHEMBL4065874 | — | — | 1 | 6.55 |
| CHEMBL1077604 | ROHITUKINE | — | 1 | 6.52 |
| CHEMBL4105395 | — | — | 1 | 6.51 |
| CHEMBL4087077 | — | — | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4079206 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4103469 | — | IC50 | = | 11.5 | nM | 7.94 |
| CHEMBL4066369 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4100359 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL4074270 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4094775 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4065874 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL1077604 | ROHITUKINE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4105395 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4087077 | — | IC50 | = | 350.0 | nM | 6.46 |