Assay Detail

CHEMBL4048701

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Binding

Inhibition of CLK4 (unknown origin)

ChEMBL ↗

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Target

Dual specificity protein kinase CLK4 (CHEMBL4203) ↗

Open DB target context

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Dual specificity protein kinase CLK4 (CHEMBL4203) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Dual specificity protein kinase CLK4

CHEMBL4203

Anchored from Assay target.

Protein identity Dual specificity protein kinase CLK4

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Dual specificity protein kinase CLK4 (CHEMBL4203) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition.

Reich SH, Sprengeler PA, Chiang GG, Appleman JR, Chen J, Clarine J, Eam B, Ernst JT, Han Q, Goel VK, Han EZR, Huang V, Hung INJ, Jemison A, Jessen KA, Molter J, Murphy D, Neal M, Parker GS, Shaghafi M, Sperry S, Staunton J, Stumpf CR, Thompson PA, Tran C, Webber SE, Wegerski CJ, Zheng H, Webster KR.
J Med Chem (2018) 61 : 3516 -3540
PubMed 29526098 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.10	6.10

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4073443	TOMIVOSERTIB	2.0	1	6.10

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4073443	TOMIVOSERTIB	IC50	=	787.0	nM	6.10