Assay Detail
Binding
CHEMBL4048749
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of recombinant human ABCG2 ATPase activity expressed in baculovirus infected High five insect cell membranes after 20 mins by ascorbic acid ammonia molybdate reaction-based colorimetric method
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Broad substrate specificity ATP-binding cassette transporter ABCG2 (CHEMBL5393) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
New Inhibitors of Breast Cancer Resistance Protein (ABCG2) Containing a 2,4-Disubstituted Pyridopyrimidine Scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 35 | 7.53 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4101737 | — | — | 1 | 8.70 |
| CHEMBL4073213 | — | — | 1 | 8.52 |
| CHEMBL4091528 | — | — | 1 | 8.40 |
| CHEMBL4072298 | — | — | 1 | 8.40 |
| CHEMBL4094899 | — | — | 1 | 8.40 |
| CHEMBL4074563 | — | — | 1 | 8.30 |
| CHEMBL4081623 | — | — | 1 | 8.10 |
| CHEMBL4064296 | — | — | 1 | 8.10 |
| CHEMBL1195084 | — | — | 1 | 7.96 |
| CHEMBL4082782 | — | — | 1 | 7.96 |
| CHEMBL4099250 | — | — | 1 | 7.92 |
| CHEMBL4073354 | — | — | 1 | 7.89 |
| CHEMBL547193 | — | — | 1 | 7.89 |
| CHEMBL2158558 | — | — | 1 | 7.85 |
| CHEMBL4075963 | — | — | 1 | 7.85 |
| CHEMBL4076800 | — | — | 1 | 7.80 |
| CHEMBL4060914 | — | — | 1 | 7.80 |
| CHEMBL4077346 | — | — | 1 | 7.80 |
| CHEMBL4069582 | — | — | 1 | 7.70 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 7.52 |
| CHEMBL4083745 | — | — | 1 | 7.50 |
| CHEMBL4072305 | — | — | 1 | 7.33 |
| CHEMBL4063711 | — | — | 1 | 7.14 |
| CHEMBL1194993 | — | — | 1 | 7.14 |
| CHEMBL1410991 | — | — | 1 | 7.14 |
| CHEMBL4094904 | — | — | 1 | 7.07 |
| CHEMBL4066611 | — | — | 1 | 6.94 |
| CHEMBL4070627 | — | — | 1 | 6.85 |
| CHEMBL4075334 | — | — | 1 | 6.85 |
| CHEMBL4104361 | — | — | 1 | 6.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4101737 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4073213 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4091528 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4072298 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4094899 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4074563 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4081623 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4064296 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1195084 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4082782 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4099250 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4073354 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL547193 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2158558 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4075963 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4060914 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4076800 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4077346 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4069582 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL50 | QUERCETIN | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4083745 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4072305 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4063711 | — | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL1194993 | — | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL1410991 | — | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4094904 | — | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL4066611 | — | EC50 | = | 116.0 | nM | 6.94 |
| CHEMBL4070627 | — | EC50 | = | 141.0 | nM | 6.85 |
| CHEMBL4075334 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4104361 | — | EC50 | = | 145.0 | nM | 6.84 |
| CHEMBL4069654 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4094267 | — | EC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL4072482 | — | EC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL4077318 | — | EC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL4088022 | — | EC50 | - | — | - |