Assay Detail
Binding
CHEMBL4048890
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1-[3-(4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1) as a Model for the Rational Design of a Novel Class of Brain Penetrant Ligands with High Affinity and Selectivity for Dopamine D4 Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.38 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4093527 | — | — | 1 | 6.30 |
| CHEMBL4080675 | — | — | 1 | 5.87 |
| CHEMBL4098720 | — | — | 1 | 5.63 |
| CHEMBL4072818 | — | — | 1 | 5.52 |
| CHEMBL4091231 | — | — | 1 | 5.33 |
| CHEMBL4063176 | — | — | 1 | 5.18 |
| CHEMBL4091058 | — | — | 1 | 5.17 |
| CHEMBL4064222 | — | — | 1 | 5.15 |
| CHEMBL4074104 | — | — | 1 | 4.85 |
| CHEMBL4085780 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4093527 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL4080675 | — | Ki | = | 1348.96 | nM | 5.87 |
| CHEMBL4098720 | — | Ki | = | 2344.23 | nM | 5.63 |
| CHEMBL4072818 | — | Ki | = | 3019.95 | nM | 5.52 |
| CHEMBL4091231 | — | Ki | = | 4677.35 | nM | 5.33 |
| CHEMBL4063176 | — | Ki | = | 6606.93 | nM | 5.18 |
| CHEMBL4091058 | — | Ki | = | 6760.83 | nM | 5.17 |
| CHEMBL4064222 | — | Ki | = | 7079.46 | nM | 5.15 |
| CHEMBL4074104 | — | Ki | = | 14125.38 | nM | 4.85 |
| CHEMBL4085780 | — | Ki | = | 17782.79 | nM | 4.75 |