Assay Detail
Binding
CHEMBL4049525
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Arabidopsis thaliana HPPD expressed in Escherichia coli T7 expression system using HPPA as substrate preincubated for 30 mins followed by substrate addition measured for 20 mins by HGA dioxygenase enzyme coupled spectrophotometric method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Arabidopsis thaliana |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
4-hydroxyphenylpyruvate dioxygenase (CHEMBL2242740) ↗| Type | SINGLE PROTEIN |
| Organism | Arabidopsis thaliana |
Publication
4-Hydroxyphenylpyruvate Dioxygenase and Its Inhibition in Plants and Animals: Small Molecules as Herbicides and Agents for the Treatment of Human Inherited Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.92 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1230467 | — | — | 1 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1230467 | — | IC50 | = | 12.0 | nM | 7.92 |