Assay Detail
Binding
CHEMBL4049538
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Arabidopsis thaliana HPPD expressed in Escherichia coli JM105 using HPPA as substrate after preincubated for 15 min followed by substrate addition by HPLC analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Arabidopsis thaliana |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
4-hydroxyphenylpyruvate dioxygenase (CHEMBL2242740) ↗| Type | SINGLE PROTEIN |
| Organism | Arabidopsis thaliana |
Publication
4-Hydroxyphenylpyruvate Dioxygenase and Its Inhibition in Plants and Animals: Small Molecules as Herbicides and Agents for the Treatment of Human Inherited Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.65 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL367881 | (+)-USNIC ACID | — | 1 | 7.16 |
| CHEMBL399910 | PINOCEMBRIN | 2.0 | 1 | 4.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL367881 | (+)-USNIC ACID | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL399910 | PINOCEMBRIN | IC50 | = | 73000.0 | nM | 4.14 |